• Publications
  • Influence
Participation of different 5-HT receptors in the memory process in rats and its modulation by the serotonin depletor p-chlorophenylalanine.
TLDR
The memory effects of agonists and antagonists of some serotonin (5-HT) receptor subtypes were examined in experiments on rats using an active avoidance method (shuttle-box); the results obtained show different participation of 5-HT1A, 5- HT2 and 4-HT3 receptors in the mechanisms of the memory process; the nature of this involvement is modulated by the brain level of serotonin. Expand
Learning and memory in rats exposed pre- and postnatally to alcohol. An attempt at pharmacological control.
TLDR
Using conditioned-reflex methods for active and passive avoidance with punishment reinforcement, pronounced memory deficits in 12-week old rats exposed perinatally to alcohol are found and nootropics could be used to decrease the cognitive disturbances in some humans born to alcoholic mothers. Expand
Changes in brain opiate receptors in rats with isolation syndrome.
TLDR
It is found that social isolation induced a decrease in the number of opiate receptors in rat frontal cortex, striatum, hippocampus and periaqueductal grey matter, and this decrease was most pronounced in isolated aggressive rats. Expand
Changes in the brain biogenic monoamines of rats, induced by piracetam and aniracetam.
TLDR
The results obtained show that the changes induced in the cerebralBiogenic monoamines participate in the mechanism of action of piracetam and aniracetam, whereby it seems that the analogies and differences in their effects on the cerebral biogenic monoamine play a definite role for the observed analogiesand differences in the behavioural effects of these two "nootropic" compounds. Expand
Memory effects of standardized extracts of Panax ginseng (G115), Ginkgo biloba (GK 501) and their combination Gincosan (PHL-00701).
TLDR
The results suggest that the Panax ginseng G115 and the Ginkgo biloba GK501 extracts possess properties similar in every respect to those of nootropic drugs. Expand
Age-related changes in rat brain dopaminergic receptors.
TLDR
The present results, particularly those concerning the cerebral cortex, suggest an age-related decrease also in the number of 5-HT receptors in this cerebral structure. Expand
Enkephalin receptor changes in rat brain during aging.
TLDR
It was found that the number (Bmax) of brain enkephalin (Enk) receptors decreased with aging, and the studies with repeated administration of L-dopa or haloperidol provided further evidence for interactions between opiate and dopaminergic systems. Expand
Effects of meclofenoxate on the level and turnover of biogenic monoamines in the rat brain.
TLDR
The results suggest the neurochemical basis of the psychotropic and neuroendocrine effects of meclofenoxate, which decreased serotonin (5-HT) turnover in the cortex, striatum and hypothalamus and increased it in the pons. Expand
Participation of the serotonergic system in the memory effects of Ginkgo biloba L. and Panax ginseng C. A. Mey
TLDR
The 7‐day oral administration of the extracts from Ginkgo biloba and Panax ginseng as well as their combination PHL‐00701 (Gincosan®) produced changes in rat behaviour suggesting memory‐enhancing effects, suggesting the participation of the serotonergic transmitter system as an important neurochemical correlate of rat behaviour and of the memory effects of the drugs studied. Expand
Effect of CDP-choline on learning and memory processes in rodents.
TLDR
CDP-choline is defined as a substance capable of improving cognitive levels and its ability to improve learning and memory in rats and mice is documented. Expand
...
1
2
3
...