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An international standardization programme towards the application of gene expression profiling in routine leukaemia diagnostics: the Microarray Innovations in LEukemia study prephase
- A. Kohlmann, T. Kipps, +21 authors T. Haferlach
- British journal of haematology
- 1 September 2008
Gene expression profiling has the potential to enhance current methods for the diagnosis of haematological malignancies. Here, we present data on 204 analyses from an international standardization… Expand
A diagnostic polymerase chain reaction assay for Zika virus
- M. Balm, C. K. Lee, H. K. Lee, L. Chiu, E. Koay, J. Tang
- Journal of medical virology
- 1 September 2012
Zika virus (ZIKV) is a mosquito‐borne flavivirus. Infection results in a dengue‐like illness with fever, headache, malaise, and a maculopapular rash. Nearly all cases are mild and self‐limiting but… Expand
Reliability of Tissue Microarrays in Detecting Protein Expression and Gene Amplification in Breast Cancer
Tissue microarrays allow high throughput molecular profiling of diagnostic or predictive markers in cancer specimens and rapid validation of novel potential candidates identified from genomic and… Expand
Microsieve lab-chip device for rapid enumeration and fluorescence in situ hybridization of circulating tumor cells.
Herein we present a lab-chip device for highly efficient and rapid detection of circulating tumor cells (CTCs) from whole blood samples. The device utilizes a microfabricated silicon microsieve with… Expand
Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection
Influenza A H1N1/2009 virus that emerged from swine rapidly replaced the previous seasonal H1N1 virus. Although the early emergence and diversification of H1N1/2009 is well characterized, the ongoing… Expand
Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells.
- Angeline Wei Ling Chua, Hui Sin Hay, +7 authors G. Sethi
- Biology, Medicine
- Biochemical pharmacology
- 15 November 2010
The CXC chemokine receptor-4 (CXCR4), a Gi protein-coupled receptor for the ligand CXCL12/stromal cell-derived factor-1α (SDF-1α), is known to be expressed in various tumors. This receptor mediates… Expand
Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro‐apoptotic transcriptional responses: a microarray analysis
- Elaine H. J. Yew, N. Cheung, +11 authors B. Halliwell
- Biology, Medicine
- Journal of neurochemistry
- 1 August 2005
Although inhibition of the ubiquitin proteasome system has been postulated to play a key role in the pathogenesis of neurodegenerative diseases, studies have also shown that proteasome inhibition can… Expand
Denaturing gradient-gel electrophoresis screening of familial defective apolipoprotein B-100 in a mixed Asian cohort: two cases of arginine3500-->tryptophan mutation associated with a unique…
The Arg-to-Trp substitution at codon 3500 in the apolipoprotein (apo) B-100 gene is established as a cause of familial defective apo B-100 (FDB), a functional mutation, resulting in reduced LDL… Expand
Tyrosine phosphorylation of PP2A is regulated by HER-2 signalling and correlates with breast cancer progression.
Activation of HER-2/neu leads to multiple signalling cascades and plays a vital role in cell survival and growth. We used a signal transduction antibody array to characterize the tyrosine… Expand
A prospective clinical study on the use of reverse transcription-polymerase chain reaction for the early diagnosis of Dengue fever.
- K. Singh, A. Lale, +4 authors E. Koay
- Biology, Medicine
- The Journal of molecular diagnostics : JMD
- 1 November 2006
Laboratory testing for dengue virus is used to confirm the diagnosis of dengue virus infection and to differentiate dengue from other febrile tropical illnesses. There are few data on the clinical… Expand