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Microarray analysis of radiation response genes in primary human fibroblasts.
Extracellular Vesicles Mediate Radiation-Induced Systemic Bystander Signals in the Bone Marrow and Spleen
The role of EVs in transmitting certain radiation effects is proved, identified miRNAs carried by EVs potentially responsible for these effects, and showed that the pattern of changes was often different in the directly irradiated and EV-recipient bystander mice, suggesting different mechanisms.
RENEB intercomparison exercises analyzing micronuclei (Cytokinesis-block Micronucleus Assay)
The results of the two exercises performed by the RENEB network demonstrate that the micronucleus assay is a useful tool for large-scale radiation emergencies, and can be successfully implemented within a large network of laboratories.
Analysis of the common deletions in the mitochondrial DNA is a sensitive biomarker detecting direct and non-targeted cellular effects of low dose ionizing radiation.
Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans – joint RENEB and EURADOS inter-laboratory comparisons
Inter-comparisons of four new dosimetry methods proposed or developed show good agreement between the laboratories and methods within the expected levels of uncertainty, and demonstrate that there is a lot of potential for each of the candidate techniques.
Extracellular vesicles mediate low dose ionizing radiation-induced immune and inflammatory responses in the blood
- T. Szatmári, E. Persa, K. Lumniczky
- Biology, MedicineInternational journal of radiation biology
- 18 January 2019
Low and high dose effects overlapped both in EV-mediated alterations in signaling pathways leading to RIBE and in their systemic manifestations.
Growth Differentiation Factor-15 (GDF-15) is a potential marker of radiation response and radiation sensitivity.
Radiotherapy-Induced Changes in the Systemic Immune and Inflammation Parameters of Head and Neck Cancer Patients
Radiotherapy-induced changes in systemic immune parameters of head and neck cancer patients are demonstrated and proposed markers suitable for patient stratification worth investigating in larger patient cohorts are proposed.
TP53inp1 Gene Is Implicated in Early Radiation Response in Human Fibroblast Cells
- N. Sándor, Boglárka Schilling-Tóth, H. Hegyesi
- Biology, MedicineInternational journal of molecular sciences
- 1 October 2015
It is proposed that silencing of TP53inp1 leads radiation induced autophagy impairment and induces accumulation of damaged mitochondria in primary human fibroblasts and enhanced radiation sensitivity of fibroblast cells.
RENEB accident simulation exercise
- B. Brzozowska, E. Ainsbury, A. Wójcik
- MedicineInternational Journal of Radiation Biology
- 2 January 2017
The procedures in the case of radiological event were successfully established and tested and each participant received training in both the role of a reference laboratory (activating the network) and of a service laboratory (responding to an activation request).