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Mitochondria as a Target for Neurotoxins and Neuroprotective Agents
Abstract: Mitochondrial permeability transition pores represent a multiprotein complex that includes components of both inner and outer membrane. The pores regulate transport of ions and peptides inExpand
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Dimebon and Tacrine Inhibit Neurotoxic Action of β-Amyloid in Culture and Block L-type Ca2+ Channels
Dimebon, a Russian-made drug, inhibited toxic effects of beta -amyloid on cultured neurons. Excessive accumulation of beta-amyloid in the brain is characteristic of Alzheimer dementias. AntialzheimerExpand
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Effect of beta-Amyloid Peptide Fragment 25-35 on Nonselective Permeability of Mitochondria
Beta-Amyloid peptide fragment 25-35 potentiated phosphate- and calcium-induced opening of mitochondrial channels and caused swelling of mitochondria (even without exogenous calcium and phosphate).Expand
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Substrate activation in the thrombin-catalyzed hydrolysis of synthetic esters of arginine.
Abstract The kinetic properties of α-thrombin and product of its limited trypsin-sepharose proteolysis - β-thrombin in wide range of synthetic substrate concentration were studied. SubstrateExpand
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Dimebon attenuates the Aβ-induced mitochondrial permeabilization.
The currently available experimental data supports the hypothesis that the neuroprotective effect of dimebon is related to the protection of the brain-mitochondria from neurodegeneration. In thisExpand
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Synthesis and antioxidative activity of metalloporphyrins bearing 2,6-di-tert-butylphenol pendants.
The novel metalloporphyrins (M=HH, Fe, Mn, Co, Cu, Zn) bearing 2,6-di-tert-butylphenol pendants as antioxidant substituents, and a long chain hydrocarbon palmitoyl group have been synthesized. TheExpand
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Interaction of docosahexaenoic acid derivatives with mitochondria
187 The effect of docosahexaenoic acid and its derivatives (amide with dopamine and esters with ethylene glycol and nitroethylene glycol) on the functioning of isolated rat liver mitochondria wasExpand
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P.1.c.037 Mitochondria as the memantine target
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Novel ferrocene-based inhibitor of proteins glycation
Antioxidant and antiglycating activities of 2,6-di-tert-butyl-4-[N-(4-pyridyl)iminomethyl]phenol (1), 2,6-di-tert-butyl-4-[N-(3-pyridylmethyl)-iminomethyl]phenol (2) andExpand
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