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Incidence and prevalence of multiple sclerosis in Europe: a systematic review
BackgroundMultiple sclerosis (MS) is the most common cause of neurological disability in young adults worldwide and approximately half of those affected are in Europe. The assessment of differentialExpand
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Incidence and Prevalence of Multiple Sclerosis in the Americas: A Systematic Review
Background: The incidence and prevalence of multiple sclerosis (MS) varies considerably around the world. No previous study has performed a comprehensive review examining the incidence and prevalenceExpand
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The natural history of primary progressive multiple sclerosis
Background: Primary progressive multiple sclerosis (PPMS) carries the worst prognosis of the multiple sclerosis (MS) subtypes and is currently untreatable. A previous analysis of the British ColumbiaExpand
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Relative mortality and survival in multiple sclerosis: findings from British Columbia, Canada
Objective To examine mortality and factors associated with survival in a population based multiple sclerosis (MS) cohort. Methods Clinical and demographic data of MS patients registered with theExpand
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The natural history of secondary progressive multiple sclerosis
Background The onset of secondary progression is a pivotal event in the course of relapsing–remitting (RR) multiple sclerosis (MS). Patients with secondary progressive MS (SPMS) experience continuousExpand
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Association between use of interferon beta and progression of disability in patients with relapsing-remitting multiple sclerosis.
CONTEXT Interferon beta is widely prescribed to treat multiple sclerosis (MS); however, its relationship with disability progression has yet to be established. OBJECTIVE To investigate theExpand
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Cardiotoxicity and other adverse events associated with mitoxantrone treatment for MS
Background: Mitoxantrone is used for aggressive multiple sclerosis (MS), but concerns about safety, including cardiotoxicity and other laboratory measures, prevail. Objective: To evaluate theExpand
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Cancer risk in multiple sclerosis: findings from British Columbia, Canada.
Findings regarding cancer risk in people with multiple sclerosis have been inconsistent and few studies have explored the possibility of diagnostic neglect. The influence of a relapsing-onset versusExpand
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Examining the effects of comorbidities on disease-modifying therapy use in multiple sclerosis
Objective: Comorbidities are common in multiple sclerosis (MS) and adversely affect health outcomes. However, the effect of comorbidity on treatment decisions in MS remains unknown. We aimed toExpand
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Language and behavior in children with Sotos syndrome.
OBJECTIVE To examine language and behavior in children with Sotos syndrome, an overgrowth syndrome involving advanced bone age, characteristic facies, and developmental disability. METHODExpand
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