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BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas.
BRAF mutations are associated with distinct phenotypical and biological properties of papillary carcinomas and may participate in progression to poorly differentiated and anaplastic carcinomas. Expand
High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.
It is shown that a somatic mutation of BRAF, V599E, is the most common genetic change in PTCs, and represents a unique paradigm of human tumorigenesis through mutation of three signaling effectors lying in tandem. Expand
Comparative Analyses of the Complete Genome Sequences of Pierce's Disease and Citrus Variegated Chlorosis Strains of Xylella fastidiosa
The genome sequence of X. fastidiosa (Temecula strain) is reported and it is concluded that these two organisms have identical metabolic functions and are likely to use a common set of genes in plant colonization and pathogenesis, permitting convergence of functional genomic strategies. Expand
Comparative Genomics of Two Leptospira interrogans Serovars Reveals Novel Insights into Physiology and Pathogenesis
Genome sequence analysis elucidates many of the novel aspects of leptospiral physiology relating to energy metabolism, oxygen tolerance, two-component signal transduction systems, and mechanisms of pathogenesis. Expand
Brazilian coffee genome project: an EST-based genomic resource
The Brazilian Coffee Genome Project was designed with the objective of making modern genomics resources available to the coffee scientific community, working on different aspects of the coffee production chain. Expand
MicroRNA miR-146b-5p regulates signal transduction of TGF-β by repressing SMAD4 in thyroid cancer
The results confirm the oncogenic role of miR-146b-5p in thyroid follicular cells and contribute to knowledge regarding the modulation of TGF-β signal transduction by miRNAs in PTCs. Expand
Endogenous expression of HrasG12V induces developmental defects and neoplasms with copy number imbalances of the oncogene
  • X. Chen, N. Mitsutake, +11 authors J. Fagin
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 12 May 2009
Tumor initiation by HrasG12V likely requires augmentation of signal output, which in papillomas and angiosarcomas is achieved via increased Hras-gene copy number, which may be favored by a higher mutation frequency in cells expressing the oncoprotein. Expand
The genome sequence of the gram-positive sugarcane pathogen Leifsonia xyli subsp. xyli.
Findings are consistent with the nutritionally fastidious behavior exhibited by L. xyli and suggest an ongoing adaptation to the restricted ecological niche it inhabits, and are similar to those in free-living organisms. Expand
Does prolonged oral exposure to cyanide promote hepatotoxicity and nephrotoxicity?
An increase in the thiocyanate levels was verified in all experimental groups and in the thyroid gland an increase was observed in the number of reabsorption vacuoles on follicular colloid, in a dose-dependent manner, in all animals of the experimental groups. Expand
Effects of let-7 microRNA on Cell Growth and Differentiation of Papillary Thyroid Cancer.
It is reported that RET/PTC3 oncogenic activation in PCCL3 rat thyroid cells markedly reducesLet-7f expression, and stable transfection of let-7 microRNA in TPC-1 cells, which harbor RET/ PTC1 rearrangement, inhibits MAPK activation. Expand