E. Kimble

Publications31
h-index12
Citations576
Highly Influential Citations12
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Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase‐2
TLDR
Lumiracoxib is a highly selective COX‐2 inhibitor with anti‐inflammatory, analgesic and antipyretic activities comparable with diclofenac, the reference NSAID, but with much improved gastrointestinal safety.
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Preclinical pharmacology of robenacoxib: a novel selective inhibitor of cyclooxygenase-2.
TLDR
Results of preclinical studies in rats studies suggest that robenacoxib has an attractive pharmacological profile for potential use in the intended target species, cats and dogs.
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Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice.
TLDR
In vitro, ex vivo, and in vivo assays demonstrate that WYE-151650 is efficacious in mouse CIA despite JAK-3 selectivity, and question the need to broadly inhibit Jak-1,JAK-2, or Tyk-2-dependent cytokine pathways for efficacy.
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Novel C5a receptor antagonists regulate neutrophil functions in vitro and in vivo.
TLDR
C5aRAM and C5aRAD are novel, potent C 5a receptor antagonists devoid of agonist or proinflammatory activity with demonstrated efficacy in vitro and in vivo.
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Effects of diclofenac sodium on arachidonic acid metabolism.
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Characterization of CGS 8515 as a selective 5-lipoxygenase inhibitor using in vitro and in vivo models.
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The effects of diclofenac sodium on arachidonic acid metabolism.
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CGS 15435A, a thromboxane synthetase inhibitor with an extended duration of action: a comparison with dazoxiben.
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Characterization of CGS 8515 as a selective 5-lipoxygenase (5-LO) inhibitor.
TLDR
Ex vivo and in vivo studies with rats showed that CGS 8515 significantly inhibited A23187-induced formation of LTs in whole blood and in the lung, and significantly suppressed exudate volume and leukocyte migration in the carrageenan-induced pleurisy and sponge models in the rat.
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Antimicrobial effectiveness of Locacorten-Vioform cream in Secondary infections of common dermatoses.
In a double-blind study involving 430 patients, Locacorten (0.02%)-Vioform (3%) cream was found to be highly effective in the treatment of dermatological conditions complicated by secondary bacterial…
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