• Publications
  • Influence
PDZ domain proteins of synapses
  • E. Kim, M. Sheng
  • Medicine, Biology
  • Nature Reviews Neuroscience
  • 1 October 2004
PDZ domains are protein-interaction domains that are often found in multi-domain scaffolding proteins. PDZ-containing scaffolds assemble specific proteins into large molecular complexes at definedExpand
  • 1,412
  • 104
Shank, a Novel Family of Postsynaptic Density Proteins that Binds to the NMDA Receptor/PSD-95/GKAP Complex and Cortactin
NMDA receptors are linked to intracellular cytoskeletal and signaling molecules via the PSD-95 protein complex. We report a novel family of postsynaptic density (PSD) proteins, termed Shank, thatExpand
  • 824
  • 89
Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ
Modular PDZ domains, found in many cell junction-associated proteins, mediate the clustering of membrane ion channels by binding to their C-terminus. The X-ray crystallographic structures of theExpand
  • 1,053
  • 79
Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases
ANCHORING of ion channels at specific subcellular sites is critical for neuronal signalling, but the mechanisms underlying channel localization and clustering are largely unknown (reviewed in ref.Expand
  • 959
  • 65
GKAP, a Novel Synaptic Protein That Interacts with the Guanylate Kinase-like Domain of the PSD-95/SAP90 Family of Channel Clustering Molecules
The molecular mechanisms underlying the organization of ion channels and signaling molecules at the synaptic junction are largely unknown. Recently, members of the PSD-95/SAP90 family of synapticExpand
  • 485
  • 42
Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function
Autism spectrum disorder (ASD) is a group of conditions characterized by impaired social interaction and communication, and restricted and repetitive behaviours. ASD is a highly heritable disorderExpand
  • 424
  • 40
Heteromultimerization and NMDA Receptor-Clustering Activity of Chapsyn-110, a Member of the PSD-95 Family of Proteins
Chapsyn-110, a novel membrane-associated putative guanylate kinase (MAGUK) that binds directly to N-methyl-D-aspartate (NMDA) receptor and Shaker K+ channel subunits, is 70%-80% identical to, andExpand
  • 514
  • 39
Interaction of the ERC Family of RIM-binding Proteins with the Liprin-α Family of Multidomain Proteins*
Liprin-α/SYD-2 is a family of multidomain proteins with four known isoforms. One of the reported functions of liprin-α is to regulate the development of presynaptic active zones, but the underlyingExpand
  • 172
  • 31
Regulation of Dendritic Spine Morphology by SPAR, a PSD-95-Associated RapGAP
The PSD-95/SAP90 family of scaffold proteins organizes the postsynaptic density (PSD) and regulates NMDA receptor signaling at excitatory synapses. We report that SPAR, a Rap-specificExpand
  • 370
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The postsynaptic organization of synapses.
  • M. Sheng, E. Kim
  • Medicine, Biology
  • Cold Spring Harbor perspectives in biology
  • 1 December 2011
The postsynaptic side of the synapse is specialized to receive the neurotransmitter signal released from the presynaptic terminal and transduce it into electrical and biochemical changes in theExpand
  • 322
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