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Experimental chemotherapy with Allium sativum (Liliaceae) methanolic extract in rodents infected with Leishmania major and Leishmania donovani.
TLDR
Since the mechanism of action for the methanolic extract is apparently immunomodulatory, garlic compounds could be purified and tried as complementary medicine in the management of leishmaniases. Expand
Anti-parasitic activity and cytotoxicity of selected medicinal plants from Kenya.
TLDR
Leishmania major infected macrophages treated with methanol extracts of Suregada zanzibariensis and Aloe nyeriensis var kedongensis and pentostam had infection rates of 28+/-2.11, 30+/-1.22 and 40+/-3.69%, respectively at 1000 microg/ml, indicating better anti-leishmanial activity for the extracts. Expand
Synthesis and synergistic antimycobacterial screening of chlorpromazine and its metabolites
The antimycobacterial activities of chlorpromazine and its metabolites were evaluated alone and in combination with antitubercular drugs. Although associated with limited antimycobacterial activityExpand
Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery.
TLDR
This review article introduces a refinement of traditional drug repositioning and repurposing strategies involving the development of drugs that are based on the active metabolite(s) of parental compounds with demonstrated efficacy, and describes an approach to repositioned the natural product antibiotic, fusidic acid, for use against Mycobacterium tuberculosis. Expand
Esterase phenotyping in human liver in vitro: specificity of carboxylesterase inhibitors
TLDR
The work was aimed at summarizing the selectivity of esterase inhibitors for carboxylesterases 1 and 2 in the human liver to clarify their suitability for ester enzyme phenotyping. Expand
Antiplasmodial and cytotoxicity activities of some selected plants used by the Maasai community, Kenya
TLDR
In the continuous search for these new antimalarial compounds, extracts from five medicinal plants from the Maasai community in Kenya were tested against P. falciparum (D6; chloroquine sensitive and W2; chlorquine resistant strains). Expand
Toxicity and efficacy of aqueous crude extracts from Allium sativum, Callistemon citrinus and Moringa stenopetala against L. Major
TLDR
It was concluded that crude aqueous extracts of A. sativum, M. stenopetala, and C. citrinus show antileishmanial activity at low toxicity and inclusion of garlic and moringa in the diets of people in leishmaniases foci should be emphasized. Expand
In vitro and in vivo activities of blends of crude aqueous extracts from Allium sativum L, Callistemon citrinus (Curtis) Skeels and Moringa stenopetala (Baker F) Cufodontis against Leishmania major
TLDR
In conclusion, aqueous blends of C. citrinus, A. sativum and M. stenopetala extracts that interacted additively or sy nergistically were less toxic but active against L. major. Expand
Antimicrobial activity of organic total extracts of three Kenyan medicinal plants
TLDR
This study was undertaken to screen organic extracts obtained from three Kenyan medicinal plants for antibacterial and antifungal activity as a basis for further phytochemical studies. Expand
In vivo antifertility activity and phytochemical screening of selected Kenyan medicinal plants
TLDR
The plant extracts tested exhibited antifertility activity, suggesting potential alternative to the current birth control methods, and compounds such as steroids, terpenoids, alkaloids, saponins and flavonoids present in the bioactive extracts may have contributed to the anti-fertility activity. Expand
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