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The Determination of Genetic Markers of Age-Related Cancer Pathologies in Populations from Kazakhstan
TLDR
This study revealed that deletions of GSTT1 and GSTM1 genes or the distinct point mutations of XRCC1 gene are associated with cervical and esophageal cancers, which will lead to development of screening for detection of individuals susceptible to esphageal and cervical cancers.
Association of DCC, MLH1, GSTT1, GSTM1, and TP53 gene polymorphisms with colorectal cancer in Kazakhstan
TLDR
Analysis for ethnicity and smoking for each of the investigated polymorphisms showed that some genotypes can have a predictive value for susceptibility to CRC, at least those that demonstrate statistically significant ORs either for the combined mixed population of Kazakhstan or for both main ethnic groups separately.
The genetic history of admixture across inner Eurasia
TLDR
Genome-wide data for 763 individuals from inner Eurasia reveal 3 admixture clines in present-day populations that mirror geography, illuminating the historic spread and mixture of peoples across the Eurasian steppe, taiga and tundra.
Lectin approaches for glycoproteomics in FDA-approved cancer biomarkers
TLDR
Some glycoproteome issues that make tackling the glycoproteinome particularly challenging in the cancer biomarkers field are discussed and a brief view for next generation technologies is included.
Analysis of K-ras codon 12 and TP53 mutations in patients with advanced colorectal carcinoma.
TLDR
Analysis of peripheral blood samples of CRC patients suffering from advanced carcinoma has prognostic value only for K-ras codon 12 mutations, and not for TP53 mutations.
K-ras codon 12 and not TP53 mutations are predominant in advanced colorectal cancers
TLDR
Analysis of peripheral blood samples of CRC patients suffering from advanced carcinoma has prognostic value only for K-ras codon 12 mutations, and not for TP53 mutations.
Ancient genomic time transect from the Central Asian Steppe unravels the history of the Scythians
TLDR
Genome-wide data for 111 ancient individuals retrieved from 39 archaeological sites from the first millennia BCE and CE across the Central Asian Steppe uncovered major admixture events in the Late Bronze Age forming the genetic substratum for two main Iron Age gene- pools emerging around the Altai and the Urals respectively.
G39179T DNMT3B Gene Variants in Relation to Colorectal Cancer Risk inKazakhstan Population
TLDR
It is suggested that the DNMT3B G39179T polymorphism participates in modulation of susceptibility to CRC, and was associated with an increased risk of colorectal cancer development in Kazakhstan population.
Characterizing the genetic history of admixture across inner Eurasia
TLDR
The genetic structure of Caucasus populations highlights a role of the Caucasus Mountains as a barrier to gene flow and suggests a post-Neolithic gene flow into North Caucasus populations from the steppe.
Comprehensive assessment of unutilized and obsolete pesticides impact on genetic status and health of population of Almaty region.
TLDR
The medical examinations showed that there were more individuals with high and middle levels of somatic health in the control group than in groups exposed to OCPs, and the long-term effect of the pesticide contamination of the environment on genetic status of the population was assessed by chromosomal aberration frequencies.
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