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A new cyclopyrophosphate as a bacterial antistressor?
In a number of bacteria an unusual glycosyl pyrophosphate was detected when the cells were subjected to oxidative stress, and it is suggested that this compound is the long sought after bacterial antistressor. Expand
Synthesis of a new organic pyrophosphate in large quantities is induced in some bacteria by oxidative stress.
A novel substance that represents greater than 50% of the extractable phosphorus is suggested to play a role as a bacterial antistressor and is thought to be a product of condensation of two molecules of phosphoenolpyruvate whose accumulation is prompted by conversion of intracellular NADPH into an oxidized form. Expand
The ability of bacteria to synthesize a new cyclopyrophosphate correlates with their tolerance to redox-cycling drugs: on a crossroad of chemotherapy, environmental toxicology and immunobiochemical…
- D. Ostrovsky, E. Kharatian, T. Dubrovsky, O. Ogrel, I. Shipanova, L. Sibeldina
- Biology, Medicine
- 1 December 1992
Many redox-cyclers were recently shown to induce, in some bacterial species, large-scale biosynthesis of a new 2-methylbutan-1,2,3,4-tetraol-2,4-cyclopyrophosphate believed to be involved in… Expand
The Ability of a Recombinant Escherichia coli Strain to Synthesize 2-C-Methyl-D-Erythritol-2,4-Cyclopyrophosphate Correlates with Its Tolerance to In Vitro Induced Oxidative Stress and to the…
- O. Ogrel, K. Fegeding, E. Kharatian, A. Sudarikov, D. Ostrovsky
- Biology, Medicine
- Current Microbiology
- 1 April 1996
It is suggested that the pathogenicity of Corynebacteria could be mediated through the synthesis of BOSS, and the resistance of clone 2–31 to the bactericidal action of macrophages is studied. Expand
Lysodektose--a new trisaccharide from Micrococcus lysodeikticus which is transformed into an aminoxyl free radical with the loss of an electron.
- V. Biniukov, E. Kharatian, D. Ostrovsky, A. Shashkov
- Chemistry, Medicine
- Free radical research communications
A new trisaccharide 6-0-(2-deoxy-2-(N-methyl)-hydroxylamino-beta-D- glucopyranosyl)-alpha,alpha-trehalose named lysodektose has been isolated from Micrococcus lysodeikticus and is transformed into a long lived free radical in oxygenated solutions or in the presence of K3 Fe. Expand
Interconversion of radical and nitrone forms of lysodektose--a new trisaccharide from Micrococcus lysodeikticus.
Isolated from Micrococcus lysodeikticus, 6-O-(2-deoxy-2-(N-methyl)hydroxilamino-beta-D-glucopyranosyl)-alph a-alpha- trehalose (lysodektose) is oxidized by K3Fe(CN)6 in a stepwise manner to become a… Expand
Bacteria and pesticides: a new aspect of interaction--involvement of a new biofactor.
Positively charged hydrophobic pesticides of the dipyridyl family [diquat, paraquat, benzylviologen (BV++), etc.] were shown to provoke accumulation of 2-methylbutane-1,2,3,4-tetraol-2,4-… Expand
2-C-METHYL-D-ERYTHRITOL-2,4-CYCLOPYROPHOSPHATE PARTICIPATES IN BACTERIAL OXIDATIVE STRESS REACTIONS AND THEIR PERSISTENCE IN MACROPHAGES
Heat treatment of Corynebacterium ammoniagenes leads to aeration dependent accumulation of 2-C-methyl-D-erythritol-2,4-cyclopyrophosphate.
- D. Ostrovsky, E. Kharatian, E. Lysak, I. Shipanova, L. Sibeldina
- Biology, Medicine
- 1 May 1995
2-C-methyl-D-erythritol-2,4-cyclopyrophosphate (MEC) identified as a new bacterial oxidative stress substance was shown to accumulate in Corynebacterium (Brevibacterium) ammoniagenes cells aerobically cultivated in peptone-yeast extract-glucose broth on heating for 1 hour at 45 degrees C. Expand
[Organization and chemical composition of the cell wall of gramicidin S-producing Bacillus brevis].
The morphology of cells and cell walls was studied in the Bacillus brevis G.-B. R form during its growth and gramicidin S accumulation in it. The membrane apparatus became more complicated and… Expand