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- Publications
- Influence
Selective protein covalent binding and target organ toxicity.
- S. D. Cohen, N. Pumford, +4 authors J. Hinson
- Chemistry, Medicine
- Toxicology and applied pharmacology
- 1 March 1997
Protein covalent binding by xenobiotic metabolites has long been associated with target organ toxicity but mechanistic involvement of such binding has not been widely demonstrated. Modern… Expand
Acetaminophen-induced inhibition of hepatic mitochondrial respiration in mice.
- L. L. Meyers, W. Beierschmitt, E. Khairallah, S. D. Cohen
- Chemistry, Medicine
- Toxicology and applied pharmacology
- 1 May 1988
Morphological changes are observed in mitochondria early in the course of acetaminophen (APAP) hepatotoxicity. In order to determine if functional deficits also occur, this study examined the effect… Expand
A comparative study of mouse liver proteins arylated by reactive metabolites of acetaminophen and its nonhepatotoxic regioisomer, 3'-hydroxyacetanilide.
- T. Myers, E. C. Dietz, N. Anderson, E. Khairallah, S. D. Cohen, S. Nelson
- Chemistry, Medicine
- Chemical research in toxicology
- 1 April 1995
Acetaminophen (4'-hydroxyacetanilide), a widely used analgesic/antipyretic drug, is hepatotoxic in large doses, whereas the m-hydroxy isomer of acetaminophen, 3'-hydroxyacetanilide, is not… Expand
Origin and possible significance of alanine production by skeletal muscle.
- R. Odessey, E. Khairallah, A. Goldberg
- Biology, Medicine
- The Journal of biological chemistry
- 10 December 1974
Abstract These experiments were undertaken to determine the source of alanine released by skeletal muscle and to clarify the possible relationships between this process and the degradation of… Expand
Selective protein arylation and acetaminophen-induced hepatotoxicity.
- S. D. Cohen, E. Khairallah
- Chemistry, Medicine
- Drug metabolism reviews
- 1 February 1997
More than 20 years have passed since the early reports of acute hepatotoxicity with APAP overdose. During that period investigative research to discover the "mechanism" underlying the toxicity has… Expand
Compartmentation of free amino acids for protein synthesis in rat liver.
- J. Airhart, A. Vidrich, E. Khairallah
- Biology, Medicine
- The Biochemical journal
- 1 June 1974
The concept that a general intracellular pool serves as the sole precursor of amino acids for protein biosynthesis has been vigorously debated in recent years. To help resolve this controversy, we… Expand
Differential detergent fractionation of isolated hepatocytes: Biochemical, immunochemical and two‐dimensional gel electrophoresis characterization of cytoskeletal and noncytoskeletal compartments
- M. Ramsby, G. Makowski, E. Khairallah
- Biology, Medicine
- Electrophoresis
- 1994
Two‐dimensional (2‐D) gel electrophoresis is often used in toxicologic and metabolic studies to assess treatment‐ or stage‐specific changes in protein synthesis, degradation or posttranslational… Expand
Acetaminophen nephrotoxicity in CD-1 mice. I. Evidence of a role for in situ activation in selective covalent binding and toxicity.
- S. Hart, W. Beierschmitt, D. S. Wyand, E. Khairallah, S. D. Cohen
- Chemistry, Medicine
- Toxicology and applied pharmacology
- 1 June 1994
Acetaminophen (APAP) administration (600 mg/kg, ip) to 18-hr-fasted, 3-month-old male CD-1 mice results in necrosis of the renal convoluted proximal tubules. To selectively inhibit APAP activation in… Expand
Modulation of serum growth factor signal transduction in Hepa 1-6 cells by acetaminophen: an inhibition of c-myc expression, NF-kappaB activation, and Raf-1 kinase activity.
- H. Boulares, C. Giardina, C. Navarro, E. Khairallah, S. D. Cohen
- Biology, Medicine
- Toxicological sciences : an official journal of…
- 1 April 1999
Acetaminophen (APAP) is a widely used analgesic and antipyretic that can lead to severe liver damage when taken at excessive doses. APAP toxicity results when cytochrome P450-generated APAP… Expand
Immunohistochemical localization of acetaminophen in target tissues of the CD-1 mouse: correspondence of covalent binding with toxicity.
- S. Hart, R. Cartun, D. S. Wyand, E. Khairallah, S. D. Cohen
- Medicine
- Fundamental and applied toxicology : official…
- 1995
Administration of hepatotoxic doses of acetaminophen (APAP) to mice results in necrosis, not only of liver cells but of renal proximal tubules and bronchiolar and olfactory epithelium. In the liver,… Expand