E. Kelly

Publications26
h-index14
Citations1,106
Highly Influential Citations28
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Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity.
PD134308 and PD135158 are potent and selective antagonists at the cholecystokinin type B (CCK-B) receptors with IC50 values of 1.6 nM and 3.5 nM, respectively, in the radioligand binding assay and Ke… Expand
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Evidence that [3H]Dopamine Is Taken Up and Released from Nondopaminergic Nerve Terminals in the Rat Substantia Nigra In Vitro
Abstract: Potassium chloride (25 mM) and (+)‐amphet‐amine (100 μM) both stimulated the release of radioactivity from slices of substantia nigra preincubated with [3H]3,4‐dihydroxyphenylethylamine… Expand
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The effects of pharmacological modulation of KATP on the guinea-pig isolated diaphragm.
The purpose of the present study was to investigate the functional consequences of KATP modulation in the normal and the metabolically inhibited guinea-pig isolated diaphragm using the K+ channel… Expand
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Repeated administration of N-methyl-4-phenyl 1,2,5,6-tetrahydropyridine to rats is not toxic to striatal dopamine neurones.
N-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine ( MPTP ) (10 mg/kg/day i.p.) was administered to rats for 16 days, which were then observed for a further 9-11 days. MPTP administration did not alter… Expand
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Reduced activity of acetylcholinesterase in canine tracheal smooth muscle homogenates after active immune-sensitization.
Previous investigations have suggested that immune-sensitization increases airway smooth muscle responsiveness to cholinomimetic stimulation by reducing the rate of degradation of acetylcholine. To… Expand
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The effects of dopamine and dopamine agonists on the release of 3H-GABA and 3H-5HT from rat nigral slices.
Only high micromolar concentrations of dopamine and dopamine agonists altered spontaneous and KCl-evoked release of 3H-GABA and 3H-5HT from rat nigral slices in vitro. Apomorphine (100 microM) and… Expand
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A Study into the Effect of Deep Transverse Frictional Massage to the Gastrocnemius Muscles, on Pain Pressure Threshold, Range of Dorsiflexion and Force of Muscle Contraction
SummaryThe effects of deep transverse frictional massage to the gastrocnemius muscle on (1) pain pressure threshold, (2) range of dorsiflexion and (3) force of voluntary isometric muscle contraction… Expand
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Differential anatomical location of [3H]‐N,n‐propylnorapomorphine and [3 H]‐spiperone binding sites in the striatum and substantia nigra of the rat
1 Specific [3H]‐spiperone and [3H]‐N,n‐propylnorapomorphine (NPA) binding was measured in striatum and substantia nigra of the rat following unilateral 6‐hydroxydopamine (6‐OHDA) lesions of the… Expand
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Effect of in vitro preconditioning on tracheal smooth muscle responsiveness.
We evaluated the effect of preconditioning of the isometric contractile response of canine tracheal smooth muscle (TSM) in vitro. Strips of epithelium-free TSM (n = 90) were excised from 16… Expand
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Endogenous Dopamine Functionally Activates D‐1 and D‐2 Receptors in Striatum
Abstract: Rat striatal slices incubated with the phosphodiesterase inhibitor 3‐isobutyl‐1‐methylxanthine at 1 mM were exposed to different concentrations (1–100 μM) of the cate‐cholamine‐releasing… Expand
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