Reconstitution of TGFBR2 in HCT116 colorectal cancer cells causes increased LFNG expression and enhanced N-acetyl-d-glucosamine incorporation into Notch1.
- Jennifer Lee, E. Katzenmaier, J. Kopitz, J. Gebert
- BiologyCellular Signalling
- 1 August 2016
Deciphering the galectin‐12 protein interactome reveals a major impact of galectin‐12 on glutamine anaplerosis in colon cancer cells
- E. Katzenmaier, V. Fuchs, U. Warnken, M. Schnölzer, J. Gebert, J. Kopitz
- Biology, ChemistryExperimental Cell Research
- 15 June 2019
Impact of sodium butyrate on the network of adhesion/growth-regulatory galectins in human colon cancer in vitro.
- E. Katzenmaier, S. André, J. Kopitz, H. Gabius
- BiologyAnticancer Research
- 1 October 2014
Butyrate affects the galectin network beyond galectins-1 and -3, warranting further cell biological and histochemical studies.
Recurrent frameshift neoantigen vaccine elicits protective immunity with reduced tumor burden and improved overall survival in a Lynch syndrome mouse model.
- J. Gebert, Ozkan Gelincik, M. Kloor
- Biology, MedicineGastroenterology
- 2 July 2021
Pre-clinical findings support a clinical strategy of recurrent FSP neoantigen vaccination for LS cancer immunoprevention, and show vaccination with a combination of only four FSPs significantly increased FSP-specific adaptive immunity, reduced intestinal tumor burden and prolonged overall survival.
Analyzing epigenetic control of galectin expression indicates silencing of galectin‐12 by promoter methylation in colorectal cancer
- E. Katzenmaier, M. Kloor, H. Gabius, J. Gebert, J. Kopitz
- BiologyIUBMB Life - A Journal of the International Union…
- 3 November 2017
It is demonstrated that expression of galectins‐1, −2, −7, −8, and −9 can be regulated by histone acetylation in colorectal cancer (CRC) cell lines and for the first time, detailed methylation analysis of the promoter region is provided.
(Phospho)proteomic Profiling of Microsatellite Unstable CRC Cells Reveals Alterations in Nuclear Signaling and Cholesterol Metabolism Caused by Frameshift Mutation of NMD Regulator UPF3A
- Malwina Michalak, E. Katzenmaier, J. Gebert
- BiologyInternational Journal of Molecular Sciences
- 23 July 2020
UPF3A mutations can modulate the (phospho)proteomic signature and expression of enzymes involved in cholesterol metabolism in CRC cells, UPf3A may influence other processes than NMD and loss of UPF2A expression might provide a growth advantage to MSI CRC cells.
Galectin-12 colocalizes with splicing factor-rich speckles and shuttles between the nucleus and cytoplasm in colon cancer cells
- E. Katzenmaier, H. Stark, J. Gebert, J. Kopitz
- Biology
- 1 June 2018
A genetically engineered colon cancer model cell line is established, which facilitates inducible and reconstituted expression of LGALS12 transgene at physiological levels in an isogenic background to investigate the functional impact of galectin-12 reconstitution on colon cancer tumorigenesis.
Abstract 1070: Epigenetic silencing of galectin-12 in colorectal cancer
- E. Katzenmaier, J. Gebert, M. Kloor, J. Kopitz
- Biology
- 1 August 2015
This study for the first time shows that galectin-12 promoter methylation represses galectIn-12 expression in colorectal tumor cells independent of their MSI status.