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Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition.
Microtubules are cytoskeletal polymers with two structurally and functionally distinct ends, the plus- and the minus-end. Here, we focus on the mechanisms underlying the regulation of microtubuleExpand
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CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor.
Mechanisms controlling microtubule dynamics at the cell cortex play a crucial role in cell morphogenesis and neuronal development. Here, we identified kinesin-4 KIF21A as an inhibitor of microtubuleExpand
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End-binding proteins sensitize microtubules to the action of microtubule-targeting agents
Microtubule-targeting agents (MTAs) are widely used for treatment of cancer and other diseases, and a detailed understanding of the mechanism of their action is important for the development ofExpand
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Molecular Pathway of Microtubule Organization at the Golgi Apparatus.
The Golgi apparatus controls the formation of non-centrosomal microtubule arrays important for Golgi organization, polarized transport, cell motility, and cell differentiation. Here, we show thatExpand
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Microtubule Minus-End Binding Protein CAMSAP2 Controls Axon Specification and Dendrite Development
In neurons, most microtubules are not associated with a central microtubule-organizing center (MTOC), and therefore, both the minus and plus-ends of these non-centrosomal microtubules are foundExpand
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TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays
Axon formation, the initial step in establishing neuronal polarity, critically depends on local microtubule reorganization and is characterized by the formation of parallel microtubule bundles. HowExpand
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CLASP Suppresses Microtubule Catastrophes through a Single TOG Domain
Summary The dynamic instability of microtubules plays a key role in controlling their organization and function, but the cellular mechanisms regulating this process are poorly understood. Here, weExpand
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Resolving bundled microtubules using anti-tubulin nanobodies
Microtubules are hollow biopolymers of 25-nm diameter and are key constituents of the cytoskeleton. In neurons, microtubules are organized differently between axons and dendrites, but their preciseExpand
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MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons
Polarized cargo transport is essential for neuronal function. However, the minimal basic components required for selective cargo sorting and distribution in neurons remain elusive. We found that inExpand
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Myosin-V Opposes Microtubule-Based Cargo Transport and Drives Directional Motility on Cortical Actin
Intracellular transport is driven by motor proteins that either use microtubules or actin filaments as their tracks, but the interplay between these transport pathways is poorly understood. WhereasExpand
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