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Metabolic syndrome: definitions and controversies
TLDR
It is suggested that diagnosis, prevention and treatment in children and adolescents should better focus on established risk factors rather than the diagnosis of MetS, because of its alarmingly increasing prevalence. Expand
Glucocorticoid receptor signaling in bone cells.
TLDR
The present review provides an in-depth account of the current knowledge of GR-mediated transcriptional regulation of specific genes and proteins engaged in the proliferation, differentiation, and apoptosis of bone cells (osteoblasts, osteocytes, osteoclasts) and hopes this knowledge will advance research in the development of SEGRAs with improved benefit/risk ratios. Expand
Role of Vitamin D in Atherosclerosis
TLDR
Current data is provided on the effects of vitamin D on cells directly implicated in atherosclerosis such as ECs, VSMCs, and immune cells with a focus on the underlying molecular mechanisms. Expand
Ursolic acid, a naturally occurring triterpenoid, demonstrates anticancer activity on human prostate cancer cells
TLDR
The antiproliferative and apoptotic effects of ursolic acid in PC-3 and LNCaP cells implicate its potential therapeutic use for the treatment of hormone refractory and androgen-sensitive prostate cancer. Expand
Ursolic Acid Triggers Apoptosis and Bcl-2 Downregulation in MCF-7 Breast Cancer Cells
TLDR
The UA-induced apoptosis, the PARP cleavage, and the decrease in Bcl-2 protein support the notion that UA induces apoptosis through the intrinsic mitochondrial pathway. Expand
Walnut extract (Juglans regia L.) and its component ellagic acid exhibit anti-inflammatory activity in human aorta endothelial cells and osteoblastic activity in the cell line KS483
TLDR
The present results suggest that the walnut extract has a high anti-atherogenic potential and a remarkable osteoblastic activity, an effect mediated, at least in part, by its major component ellagic acid, which implicate the beneficial effect of a walnut-enriched diet on cardioprotection and bone loss. Expand
Fatty Acids Derived from Royal Jelly Are Modulators of Estrogen Receptor Functions
TLDR
The data propose a possible molecular mechanism for the estrogenic activities of RJ's components which, although structurally entirely different from E2, mediate estrogen signaling, at least in part, by modulating the recruitment of ERα, ERβ and co-activators to target genes. Expand
Stress, Endocrine Physiology and Pathophysiology
TLDR
This chapter describes the organization and physiology of the stress system, focusing on its interactions with other CNS centers and endocrine axes, and reviews the existing evidence linking stress to pathophysiologic mechanisms implicated in the development of stress-related diseases affecting the endocrine, metabolic, gastrointestinal and immune systems. Expand
Phenolic Acid Composition, Antiatherogenic and Anticancer Potential of Honeys Derived from Various Regions in Greece
TLDR
Greek honeys are rich in phenolic acids, in particular protocatechuic and p-hydroxybenzoic acid and exhibit significant antioxidant, anticancer and antiatherogenic activities which may be attributed, at least in part, to their phenolic acid content. Expand
Glucocorticoid receptor signaling and prostate cancer.
TLDR
This review focuses on how GCs induce effects via the GR-mediated transcriptional regulation of specific genes known to play key roles in cellular/tissue functions, including growth, apoptosis, inflammation, metastasis, differentiation, cell survival and angiogenesis. Expand
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