• Publications
  • Influence
Placebo and Opioid Analgesia-- Imaging a Shared Neuronal Network
Using positron emission tomography, it is confirmed that both opioid and placebo analgesia are associated with increased activity in the rostral anterior cingulate cortex and the brainstem, indicating a related neural mechanism in placebo and opioid analgesia. Expand
The compassionate brain: humans detect intensity of pain from another's face.
Using functional magnetic resonance imaging, it is shown that not only the presence of pain but also the intensity of the observed pain is encoded in the observer's brain-as occurs during the observer’s own pain experience. Expand
Opioids in chronic non-cancer pain: systematic review of efficacy and safety
The short‐term efficacy of opioids was good in both neuropathic and musculoskeletal pain conditions, however, only a minority of patients in these studies went on to long‐term management with opioids, and conclusions concerning problems such as tolerance and addiction are not allowed. Expand
Aberrant temporal and spatial brain activity during rest in patients with chronic pain
The results imply both temporally and spatially aberrant activity of the affective pain-processing areas in patients suffering from chronic pain, including the accentuated 0.12- to 0.25-Hz fluctuations in the patient group might be related to altered activity ofThe autonomic nervous system. Expand
Morphine and alternative opioids in cancer pain: the EAPC recommendations
The revised recommendations presented here give guidance on the use of morphine and the alternative strong opioid analgesics which have been introduced in many parts of the world in recent years. Expand
Pain and other symptoms after different treatment modalities of breast cancer.
Chronic pain was more common after breast-conserving surgery than after radical surgery, and surgical complications and postoperative radiotherapy and chemotherapy increased the risk of chronic pain and other symptoms. Expand
A new definition of neuropathic pain
A new definition of neuropathic pain is published which is defined as “pain caused by a lesion or disease of the somatosensory system” ( www.iasp-pain.org/resources/painDefinition). Expand
Chronic pain after thoracic surgery: a follow‐up study
Background: The incidence of long‐term post‐thoracotomy pain is reported to be up to 67%. A relationship between the severity of acute postoperative pain and the development of chronicExpand
Effects of blocking CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone
The aim of this study was to evaluate the role of oxymorphone in mediating the opioid effects of oxycodone by means of blocking CYP2D6 with quinidine. Expand
Perioperative ketamine for acute postoperative pain.
Ketamine in subanaesthetic dose (that is a dose which is below that required to produce anaesthesia) is effective in reducing morphine requirements in the first 24 hours after surgery. Expand