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Acetaminophen-Induced Hepatotoxicity in Mice Occurs with Inhibition of Activity and Nitration of Mitochondrial Manganese Superoxide Dismutase
The data indicate that Manganese superoxide dismutase inactivation by nitration is an early event in APAP-induced hepatic toxicity. Expand
Pharmacokinetic herb-drug interactions (part 2): drug interactions involving popular botanical dietary supplements and their clinical relevance.
In Part 2 of this review, a critical examination of the pertinent scientific literature is undertaken in order to assess the interaction risk that popular dietary supplements may pose when takenExpand
Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH-018 and JWH-073 in human urine.
The liquid chromatography tandem mass spectrometry procedure coupled with an automated solid-phase extraction procedure incorporating deuterium-labeled internal standards provides rapid resolution of the (ω)- and (ω-1) metabolites with adequate sensitivity, precision, and accuracy for trace analysis in human urine. Expand
Effect of the nitro group conformation on the rat liver microsomal metabolism and bacterial mutagenicity of 2- and 9-nitroanthracene.
Results suggest that 2-NA can be metabolized to mutagenic products by nitroreduction and ring-oxidation followed by nit mirroreduction, but not nitrored reduction followed by ring- oxidation. Expand
Macrophage production of inflammatory mediators is potently inhibited by a butyric acid derivative demonstrated to inactivate antigen-stimulated T cells.
While inducing specific T cell unresponsiveness, MEB also exerts anti-inflammatory activity by acting on macrophages to suppress production of cytokines and NO. Expand
Akt activation improves oxidative phosphorylation in renal proximal tubular cells following nephrotoxicant injury.
The data show that Akt activation promotes mitochondrial respiration and ATP production in toxicant-injured RPTC by improving integrity of the respiratory chain and maintaining activities of complex I and complex III, 2) reducing decreases in DeltaPsi(m), and 3) restoring F(0)F(1)-ATPase activity. Expand
Structure-activity relationship between carboxylic acids and T cell cycle blockade.
Results underline the relationship between the ability of a carboxylic acid to inhibit histone deacetylation, and their ability to block T cell proliferation, and suggests that branching inhibits these effects. Expand
Multiple Modes of α7 nAChR Noncompetitive Antagonism of Control Agonist-Evoked and Allosterically Enhanced Currents
The results are consistent with the hypothesis that PAMs may modulate conformational states important for both channel activity and ion channel-independent signaling and show toxicity produced by PNU-120596 and choline was calcium independent and likely an apoptotic event. Expand
Potential clinical use of butyric acid derivatives to induce antigen-specific T cell inactivation.
The results presented here establish MEB as a novel means of inducing anergy in CD4(+) T cells both in vitro and in vivo and underscore the likelihood that MEB and/or other butyrate derivatives can be used as immunotherapeutic reagents. Expand
Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures.
Current Michaelis-Menten based toxicological models for mixtures such as styrene and acetaminophen would fail to detect this concentration-dependent relationship and future studies must assess the role of alternate CYP2E1 mechanisms in bioactivation of compounds to improve the accuracy of interpretations and predictions of toxicity. Expand