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[Significance of caffeine values in serum, saliva and urine--determination of pharmacokinetic data by non-invasive methods in psychopharmacologic studies].
A good correlation was found to exist between elimination half-lives for serum and saliva levels as well as serum and urine values, and the saliva level was seen to represent the serum level on a broad scale.
Dosage monitoring through measurement of serum level--a task of clinical pharmacology.
Dosage monitoring or "pharmacokinetic therapy service", respectively, covers blood level governed therapy schedule or blood level controlled dosage for certain types of therapy. It is also
[Interactions of theophylline and nifedipine].
The ventilation parameters FVC (forced vital capacity) and FEV1 (forced expiratory volume in one second) were not altered during nifedipine dosing and the results are discussed in comparison with data of literature.
[Peculiarities of theophylline therapy in childhood].
Investigations in 280 children in the age of 1 to 18 years with bronchial asthma, treated with theophylline compounds, confirm the necessity of individual dosage and surveillance of the drug level in serum and its measurement in saliva is sufficiently reliable and less molesting.
[Compliance of children with bronchial asthma in long-term therapy with theophylline retard preparations].
Better differentiation of compliance and separation from underdosing was achieved in 38 children by comparing the outpatient-controlled theophylline levels with the values obtained on an inpatient basis.
[Problems of therapeutic service in valproate therapy].
[Initial experiences with "Oranienburg" slow-release theophylline in asthma therapy of children and adolescents].
Experiences in 50 patients show that Theophyllin retard Oranienburg (280 mg theophylline) could be used as an effective bronchospasmolytic drug on conditions of mono- and combination-therapy.
[Quantitative chloramphenicol detection in serum and cerebrospinal fluid of infants with bacterial meningitis].
It is recommended that initial doses for meningitic infants be chosen according to age-adjusted dosage instructions and, from day 2 onwards, doses be corrected as a function of CSF and blood levels (CSF greater than 10micrograms.ml-1 and serum less than 50 micrograms).