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Patterns of Nicotinic Receptor Antagonism: Nicotine Discrimination Studies
It is suggested that small doses of nicotine produce their stimulus effects via α4β2* nicotine receptors, whereas larger doses of Nicotine recruit additional nicotine receptor subtypes, as revealed by drug discrimination assays in rats. Expand
Conditional ablation and recovery of forebrain neurogenesis in the mouse
Findings indicate that SVZ and DG neural stem cells differ in their capacity for repopulation, and that adult‐born neurons are not required for antidepressant responses in a common behavioral test of antidepressant efficacy, which is useful for studying how reversible depletion of adult neurogenesis influences neurophysiology, other behaviors, and neural progenitors. Expand
Differential Behavioral Tolerance to the δ-Opioid Agonist SNC80 ([(+)-4-[(αR)-α-[(2S,5R)-2,5-Dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in Sprague-Dawley
Nonpeptidic δ-opioid agonists produce a number of behaviors, such as antidepressant-like effects, locomotor stimulation, antinociception, and convulsions. To consider this class of compounds asExpand
Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats
It is suggested that delta agonist-induced antidepressant properties are independent of convulsive effects, and that it may be possible to eliminate the convulsions produced by delta agonists, further promoting their potential clinical utility. Expand
Effects of Dopamine D1 Ligands on Eye Blinking in Monkeys: Efficacy, Antagonism, and D1/D2 Interactions
Eye blink rate appears to be a robust behavioral measure that can be used to measure changes in dopaminergic D1 signaling and as a functional assay of agonist efficacy at dopamine D1 receptors. Expand
Sperm precedence and sperm storage in multiply mated red flour beetles
Examination of last-male sperm precedence patterns in doubly and triply mated Tribolium castaneum females provides insight into mechanisms of sperm storage and utilization in this species. Expand
Nonpeptidic δ-opioid Receptor Agonists Reduce Immobility in the Forced Swim Assay in Rats
The present study examined the effect of opioid receptor agonists in the rat forced swim assay. The δ-opioid receptor agonists SNC80Expand
Convulsant activity of a non-peptidic δ-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley rats
δ-Mediated convulsions do occur in rats and can be prevented without affecting the δ-mediated effects in the forced swim assay. Expand
Differential behavioral tolerance to the delta-opioid agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in
The lack of observable tolerance to the antidepressant-like effects of SNC80 indicates that this class of compounds has potential as a novel antidepressant therapy. Expand
The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats
These data suggest that reducing stress-induced increases in HPA activity alone may not be sufficient to produce antidepressant-like activity; however, reductions in H PA activity may contribute to antidepressant actions of some treatments. Expand