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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the… Expand
Interferon in oncological practice: review of interferon biology, clinical applications, and toxicities.
UNLABELLED For the past 40 years, various forms of interferon (IFN) have been evaluated as therapy in a number of malignant and non-malignant diseases. With the advent of gene cloning, large… Expand
Follow-up for Clinically Localized Renal Neoplasms: AUA Guideline.
PURPOSE The purpose of this guideline is to provide a clinical framework for follow-up of clinically localized renal neoplasms undergoing active surveillance, or following definitive therapy. … Expand
Axitinib with or without dose titration for first-line metastatic renal-cell carcinoma: a randomised double-blind phase 2 trial.
BACKGROUND Population pharmacokinetic data suggest axitinib plasma exposure correlates with efficacy in metastatic renal-cell carcinoma. Axitinib dose titration might optimise exposure and improve… Expand
Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma
Antiangiogenic therapy resistance occurs frequently in patients with metastatic renal cell carcinoma (RCC). The purpose of this study was to understand the mechanism of resistance to sunitinib, an… Expand
The PI3K/AKT Pathway and Renal Cell Carcinoma.
- Huifang Guo, P. German, +8 authors Z. Ding
- Medicine, Biology
- Journal of genetics and genomics = Yi chuan xue…
- 20 July 2015
The phosphatidylinositol 3 kinase (PI3K)/AKT pathway is genetically targeted in more pathway components and in more tumor types than any other growth factor signaling pathway, and thus is frequently… Expand
Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects.
- J. Simon, Kathryn E. Hacker, +11 authors Ian J. Davis
- Medicine, Biology
- Genome research
- 1 February 2014
Comprehensive sequencing of human cancers has identified recurrent mutations in genes encoding chromatin regulatory proteins. For clear cell renal cell carcinoma (ccRCC), three of the five commonly… Expand
Kidney Cancer, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.
- R. Motzer, E. Jonasch, +27 authors Rashmi Kumar
- Journal of the National Comprehensive Cancer…
- 1 June 2017
The NCCN Guidelines for Kidney Cancer provide multidisciplinary recommendations for the clinical management of patients with clear cell and non-clear cell renal carcinoma. These guidelines are… Expand
Everolimus Versus Sunitinib Prospective Evaluation in Metastatic Non-Clear Cell Renal Cell Carcinoma (ESPN): A Randomized Multicenter Phase 2 Trial.
BACKGROUND Sunitinib and everolimus are standard first-line and second-line therapies, respectively, in clear cell renal cell carcinoma (ccRCC). OBJECTIVE To conduct a randomized phase 2 trial… Expand
NCCN clinical practice guidelines in oncology: kidney cancer.