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White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imaging.
TLDR
Diffusion tensor imaging studies suggest altered connectivity in both schizophrenia and bipolar disorder, and results imply an overlap in white matter pathology, possibly relating to risk factors common to both disorders. Expand
Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations
TLDR
Frontotemporal functional connectivity is reduced in schizophrenia and may be associated with auditory hallucinations and previous demonstrations of hypofrontality in schizophrenia may reflect particular task requirements. Expand
A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms
TLDR
It is shown that a variant in the human NRG1 promoter region is associated with decreased activation of frontal and temporal lobe regions, increased development of psychotic symptoms and decreased premorbid IQ in subjects at high risk of schizophrenia. Expand
Magnetic resonance imaging of brain in people at high risk of developing schizophrenia
TLDR
People at high risk of developing schizophrenia for genetic reasons have several structural brain abnormalities that are similar to those in patients with the disorder, and at-risk individuals with particularly small AHC or thalami are most likely to develop schizophrenia. Expand
Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study
TLDR
The findings of reduced white matter tract integrity in the left uncinate fasciculus and left arcuate fascicule suggest that there is frontotemporal and frontoparietal structural disconnectivity in schizophrenia. Expand
Reduced in vivo binding to the serotonin transporter in the cerebral cortex of MDMA ('ecstasy') users.
TLDR
This cross-sectional association study provides suggestive evidence for specific, at least temporary, serotonergic neurotoxicity of MDMA in humans, as indicated by cortical reduction of SERT binding in primary sensory-motor cortex. Expand
Overactivation of Fear Systems to Neutral Faces in Schizophrenia
TLDR
Patients with schizophrenia show an increased response of the amygdala to neutral faces, which is sufficient to explain their apparent deficit in amygdala activation to fearful faces compared with neutral faces. Expand
The effects of a neuregulin 1 variant on white matter density and integrity
TLDR
In the current study, unaffected subjects were genotyped at the NRG1 single nucleotide polymorphism (SNP) rs6994992 ( SNP8NRG243177) locus, previously associated with increased risk for psychosis, and the effect of genetic variation at this locus on white matter density and integrity was ascertained. Expand
Grey matter changes over time in high risk subjects developing schizophrenia
TLDR
VBM was used to map changes in Grey Matter Density in 65 young adults at high risk of schizophrenia, for familial reasons, and 19 healthy young adults, over a period of approximately 2 years, and showed a different spatial pattern of reductions in GMD than those who did not in within group comparisons. Expand
Structural Gray Matter Differences between First-Episode Schizophrenics and Normal Controls Using Voxel-Based Morphometry
TLDR
Comparison of gray matter segments from T1 structural MR images of the brain in first-episode schizophrenic subjects and normal control subjects using automated voxel-based morphometry (VBM) identified significant decreases in gray matter in schizophrenics relative to the normal control group. Expand
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