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Therapeutic drug monitoring (TDM) of antifungal agents: guidelines from the British Society for Medical Mycology.
TLDR
This document reviews the available literature and provides a series of recommendations for TDM of antifungal agents. Expand
Multilocus Sequence Typing for Differentiation of Strains of Candida tropicalis
TLDR
Five of six isolates in one cluster that may acquire clade status were resistant to flucytosine, and this study adds C. tropicalis to Candida albicans and Candida glabrata as Candida species for which a multilocus sequence typing (MLST) system has been set up. Expand
Correlation between in-vitro susceptibility testing to itraconazole and in-vivo outcome of Aspergillus fumigatus infection.
TLDR
With careful selection and standardization of test conditions it is possible to generate reproducible in-vitro susceptibility data for Aspergillus spp. Expand
Candida auris: a Review of the Literature
TLDR
Genetic analysis indicates the simultaneous emergence of separate clades of this organism in different geographical locations, which will provide direction for further work in this field of Candida auris. Expand
The evolution and evaluation of a whole blood polymerase chain reaction assay for the detection of invasive aspergillosis in hematology patients in a routine clinical setting.
TLDR
A negative PCR result can be used to rule out IA and to limit the need for empirical antifungal therapy; thus, it has a role in diagnosing IA infections, especially in combination with antigen testing. Expand
Management and outcome of bloodstream infections due to Candida species in England and Wales.
TLDR
The incidence of candidaemia in England and Wales is similar to that of the USA, the majority of isolates remain sensitive to commonly used antifungal agents and mortality associated with this infection appears to be falling. Expand
Biofilm-Forming Capability of Highly Virulent, Multidrug-Resistant Candida auris
TLDR
It is reported that this highly virulent yeast has the capacity to form antifungal resistant biofilms sensitive to the disinfectant chlorhexidine in vitro. Expand
Comparative Pathogenicity of United Kingdom Isolates of the Emerging Pathogen Candida auris and Other Key Pathogenic Candida Species
TLDR
It is shown that C. auris isolates differ in their growth characteristics in vitro, with a proportion of isolates failing to release daughter cells after budding, resulting in the formation of large aggregates of cells that cannot be physically disrupted, which indicates virulence comparable to that of C. albicans, which is currently accepted as the most pathogenic member of the genus. Expand
Emergence of azole drug resistance in Candida species from HIV-infected patients receiving prolonged fluconazole therapy for oral candidosis.
TLDR
The experience with C. albicans in patients with HIV infection, suggests that the long-term azole drug use may be an important factor in the development of fluconazole resistance as such resistance was rare and transient in patients on intermittent short-term treatment. Expand
Comparison of E-Test and Broth Microdilution Methods for Antifungal Drug Susceptibility Testing of Molds
TLDR
The E test appears to be a suitable alternative procedure for testing the susceptibility of Aspergillusspp. Expand
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