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Correlation between in-vitro susceptibility testing to itraconazole and in-vivo outcome of Aspergillus fumigatus infection.
- D. Denning, S. Radford, K. Oakley, L. Hall, E. Johnson, D. Warnock
- Biology, MedicineJournal of Antimicrobial Chemotherapy
- 1 September 1997
With careful selection and standardization of test conditions it is possible to generate reproducible in-vitro susceptibility data for Aspergillus spp.
Management and outcome of bloodstream infections due to Candida species in England and Wales.
Correlation of MIC with Outcome for Candida Species Tested against Voriconazole: Analysis and Proposal for Interpretive Breakpoints
Using data generated by standardized broth microdilution and disk diffusion test methods, the Antifungal Susceptibility Subcommittee of the Clinical and Laboratory Standards Institute has proposed interpretive breakpoints for voriconazole and Candida species.
In-vitro activity of voriconazole, itraconazole and amphotericin B against filamentous fungi.
- E. Johnson, A. Székely, D. Warnock
- Biology, MedicineThe Journal of antimicrobial chemotherapy
- 1 December 1998
Voriconazole could be effective against a wide range of mould infections in humans, and was fungicidal for Phialophora parasitica.
Emergence of azole drug resistance in Candida species from HIV-infected patients receiving prolonged fluconazole therapy for oral candidosis.
- E. Johnson, D. Warnock, J. Luker, S. Porter, C. Scully
- Medicine, BiologyJournal of Antimicrobial Chemotherapy
The experience with C. albicans in patients with HIV infection, suggests that the long-term azole drug use may be an important factor in the development of fluconazole resistance as such resistance was rare and transient in patients on intermittent short-term treatment.
In vitro studies of activity of voriconazole (UK-109,496), a new triazole antifungal agent, against emerging and less-common mold pathogens
- S. Radford, E. Johnson, D. Warnock
- Biology, MedicineAntimicrobial agents and chemotherapy
- 1 April 1997
Voriconazole was more active than itraconazole against a number of hyaline molds, including several Fusarium spp.
Wild-Type MIC Distribution and Epidemiological Cutoff Values for Aspergillus fumigatus and Three Triazoles as Determined by the Clinical and Laboratory Standards Institute Broth Microdilution Methods
The results demonstrate that the WT distribution and ECVs for A. fumigatus and the mold-active triazoles were the same when determined by the CLSI or the EUCAST BMD method, which will be useful in resistance surveillance and is an important step toward the development of clinical breakpoints.
Influence of food on the pharmacokinetics of ketoconazole
- T. Daneshmend, D. Warnock, P. Williamson
- Medicine, BiologyAntimicrobial Agents and Chemotherapy
- 1 January 1984
With an increase in dose, the half-life and area under the serum concentration-time curve increased disproportionately, suggesting that the pharmacokinetics of ketoconazole may be dose dependent.
Emerging trends in the epidemiology of invasive mycoses in England and Wales (1990–9)
- T. Lamagni, B. G. Evans, M. Shigematsu, E. Johnson
- Medicine, BiologyEpidemiology and Infection
- 1 June 2001
Substantial under-reporting of Pneumocystis carinii and Cryptococcus species was apparent, and considerable numbers of superficial mycoses were mis-reported indicating a need for clarification of reporting guidelines.
In-vitro resistance to imidazole antifungals in Candida albicans.
- E. Johnson, M. Richardson, D. Warnock
- Medicine, BiologyThe Journal of antimicrobial chemotherapy
- 1 June 1984
Three strains of Candida albicans from patients with chronic mucocutaneous candidosis (CMC) who relapsed during prolonged treatment with ketoconazole were compared with three other Can. albicans…