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Oxygen Measurements in Endometrial and Trophoblastic Tissues During Early Pregnancy
It is suggested that the increase of placental PO2 at the end of the first trimester is related to the establishment of continuous maternal blood flow in the intervillous space.
Placental-related diseases of pregnancy: Involvement of oxidative stress and implications in human evolution.
It is suggested that pre-eclampsia is a three-stage disorder with the primary pathology being an excessive or atypical maternal immune response, which would impair the placentation process leading to chronic oxidative stress in theplacenta and finally to diffuse maternal endothelial cell dysfunction.
Oxidative stress
Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage.
It is recommended that basic investigations of a couple presenting with recurrent miscarriage should include obstetric and family history, age, BMI and exposure to toxins, full blood count, antiphospholipid antibodies, parental karyotype, pelvic ultrasound and/or hysterosalpingogram.
Placental Oxidative Stress: From Miscarriage to Preeclampsia
Evaluation of respiratory gases and acid-base gradients in human fetal fluids and uteroplacental tissue between 7 and 16 weeks' gestation.
Evaluated changes in intrauterine gases and acid-base gradients inside the human fetoplacental unit at 7 to 16 weeks' gestation found that early human placental tissue develops in a physiologically low-oxygen environment compared with uterine tissue.