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Effect of polychlorinated biphenyls on hepatic microsomal enzymes in the rat.
Polychlorinated biphenyls (PCB) are widely used industrial synergists and stabilizers that have been detected in various animal systems throughout the world, and recent indications are that they may possess a high chronic toxicity. Expand
The effects of sitosterol on serum lipids.
The changes in serum lipids and lipoproteins resulting from sitosterol administration are in the direction generally considered desirable in atherosclerosis, and the absence of any toxic or adverse side effects permits its further study in man. Expand
Photometric method for blood amylase by use of starch-iodine color.
Lowering of Serum Cholesterol by the Administration of a Plant Sterol
The plant sterol, beta-sitosterol, has been administered to nine subjects on unrestricted diet. A sustained reduction of serum total cholesterol and a lowering of the ratio of cholesterol to lipidExpand
Comparative distribution, excretion and metabolism of di-(2-ethylhexyl) phthalate in rats, dogs and miniature pigs.
Abstract Di-(2-ethylhexyl phthalate (DEHP) was administered in the diet to male Sprague-Dawley rats, beagle dogs and miniature swine of the Hormel strain in doses of 50 mg/kg/day for 21–28 daysExpand
Observations on the bound form of vitamin B12 in human serum.
The comparative metabolism of d-amphetamine-C14 in the rat, dog and monkey.
The distribution pattern of d -amphetamine-C 14 indicates that the rat metabolizes the drug primarily through ring hydroxylation, while, in the monkey, oxidative deamination is the primary pathway and the dog is unusual in that either pathway may be utilized. Expand
The effect of lindane and phenobarbital on microsomal enzyme induction in dogs and miniature swine.
Enzymic activities of 9000g supernatant fractions obtained from the livers of normal beagle dogs and miniature swine and of dogs and swine treated with lindane and phenobarbital are presented and a decrease in the induced state was observed in aromatic hydroxylation, azo-red reduction, and nitro-reduction reactions, although the activities of these enzymes were still higher than the values from control swine. Expand
Metabolism of chlorpheniramine-3H by the rat and dog.
When rats, but not dogs, are pretreated with nonradioactive chlorpheniramine and then given the labeled compound, the recovery of tritium in urine and feces is essentially complete in 4 days. Expand
Enzyme Induction by Polychlorinated Biphenyls Relative to Known Inducing Agents
Enzyme induction by equimolar dietary amounts of DDT, phenobarbital, and PCB was studied in rats after 30 days of treatment and found PCB was far more effective and was at least as effective as DDT. Expand