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Central pathways of pulmonary and lower airway vagal afferents.
Axon collaterals from both P-cells and RAR interneurons, and likely from NTS interneuronons in the C-fiber pathway, project to the parabrachial pontine region where they may contribute to plasticity in respiratory control and integration of respiratory control with other systems, including those that provide for voluntary control of breathing, sleep-wake behavior, and emotions. Expand
Modulation of the synaptic drive to respiratory premotor and motor neurons.
It is speculated that both GABAergic gain modulation of premotor neuronal activity and NMDA-mediated STP of phrenic activity may be neural substrates which are involved with the optimization of respiratory and non-respiratory behaviors, via adaptive and/or differential control of breathing. Expand
Pattern Formation And Rhythm Generation In The Ventral Respiratory Group
1. There is increasing evidence that the kernel of the rhythm‐generating circuitry for breathing is located within a discrete subregion of a column of respiratory neurons within the ventrolateralExpand
Effect of anodal blockade of myelinated fibers on vagal C-fiber afferents.
In anesthetized dogs, monopolar anodal block may reduce the possibility of asynchronous C-fiber discharge, which has been associated with a bipolar block of A-fibers. Expand
Systemic arterial blood pH servocontrol of mechanical ventilation.
Servocontrol of mechanical ventilation using systemic arterial blood pH, measured by a dual-function pH/PCO2 intra-arterial sensor, as the controlled variable uas carried out in 30 dogs anesthetizedExpand
Clinically relevant infusion rates of mu-opioid agonist remifentanil cause bradypnea in decerebrate dogs but not via direct effects in the pre-Bötzinger complex region.
Results indicate that mu-opioids at plasma concentrations that cause profound analgesia produce their bradypneic effect via MORs located outside the pre-BötC region through intravenous administration of clinically relevant infusion rates of remifentanil (remi). Expand
Pontine μ-opioid receptors mediate bradypnea caused by intravenous remifentanil infusions at clinically relevant concentrations in dogs.
The pontine region in which μOR agonists produce bradypnea was defined to determine whether antagonism of those μORs reverses brADypnea produced by intravenous remifentanil and Histological examination of fluorescent microsphere injections shows that the sensitive region corresponds to the parabrachial/Kölliker-Fuse complex. Expand
Respiratory rhythm generation: converging concepts from in vitro and in vivo approaches?
Here, the pre-Bötzinger complex as an essential site for rhythm generation was first identified in vitro, but has since been verified in vivo and timing signals provided by other central and peripheral neuronal areas have so far been investigated in vivo, but it is now possible to address these issues with more complex in vitro preparations. Expand
Pulmonary afferent activity recorded from sympathetic nerves.
This study in mongrel dogs, anesthetized with sodium pentobarbital, verified the existence of pulmonary receptors whose afferents traverse the right and left upper thoracic white rami communicantes, and increases in afferent activity were also observed when the pulmonary artery and veins were mechanically stimulated by probing. Expand
Effects of Sevoflurane on Excitatory Neurotransmission to Medullary Expiratory Neurons and on Phrenic Nerve Activity in a Decerebrate Dog Model
The depressive effect of sevoflurane on synaptic neurotransmission was caused by a reduction of presynaptic glutamatergic excitation and an enhancement of GABAAergic inhibition. Expand