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Phosphorylated S6 Ribosomal Protein: A Novel Biomarker of Antibody‐Mediated Rejection in Heart Allografts
We tested the hypothesis that phosphorylation of S6 ribosomal protein (S6RP), a downstream target of the PI3K/Akt/mTOR pathway, is a biomarker of antibody‐mediated rejection (AMR) in heartExpand
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Humanized Radioiodinated Minibody For Imaging of Prostate Stem Cell Antigen–Expressing Tumors
Purpose: Prostate stem cell antigen (PSCA) is a cell surface glycoprotein that is overexpressed in prostate cancer, including hormone refractory disease. Previous preclinical studies showed theExpand
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Anti-HLA Class I Antibodies Activate Endothelial Cells and Promote Chronic Rejection
Transplant recipients exhibiting a humoral immune response to the allograft demonstrate lower graft survival and increased risk for the development of chronic rejection and transplantExpand
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Microfluidic-Based 18F-Labeling of Biomolecules for Immuno–Positron Emission Tomography
Methods for tagging biomolecules with fluorine 18 as immuno–positron emission tomography (immunoPET) tracers require tedious optimization of radiolabeling conditions and can consume large amounts ofExpand
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HLA class I signal transduction is dependent on Rho GTPase and ROK.
Chronic rejection is the major limitation to long-term allograft survival. HLA class I signaling pathways have been implicated in this process because ligation of class I molecules by anti-HLAExpand
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An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors
PurposeProstate stem cell antigen (PSCA), a cell surface glycoprotein expressed in normal human prostate and bladder, is over-expressed in the majority of localized prostate cancer and most boneExpand
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Minibodies and Multimodal Chromatography Methods: A Convergence of Challenge and Opportunity.
This case study describes early phase purification process development for a recombinant anticancer minibody produced in mammalian cell culture. The minibody did not bind to protein A.Expand
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Diabodies Targeting Epithelial Membrane Protein 2 Reduce Tumorigenicity of Human Endometrial Cancer Cell Lines
Purpose: Endometrial cancer is the most common gynecologic malignancy. One promising biomarker is epithelial membrane protein 2 (EMP2), and its expression is an independent prognostic indicator forExpand
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Fluorescent Image–Guided Surgery with an Anti-Prostate Stem Cell Antigen (PSCA) Diabody Enables Targeted Resection of Mouse Prostate Cancer Xenografts in Real Time
Purpose: The inability to visualize cancer during prostatectomy contributes to positive margins, cancer recurrence, and surgical side effects. A molecularly targeted fluorescent probe offers theExpand
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Complement-independent mechanisms of antigraft antibodies in transplant arteriosclerosis and accommodation
Purpose of reviewPatients exhibiting a humoral immune response to the allograft demonstrate a lower graft survival and an increased risk of the development of transplant arteriosclerosis.Expand
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