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The Great Escape; the Hallmarks of Resistance to Antiangiogenic Therapy
The concept of antiangiogenic therapy in cancer treatment has led to the approval of different agents, most of them targeting the well known vascular endothelial growth factor pathway. DespiteExpand
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Vaccination approach to anti-angiogenic treatment of cancer.
Improvement of patient survival by anti-angiogenic therapy has proven limited. A vaccination approach inducing an immune response against the tumor vasculature combines the benefits of immunotherapyExpand
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Role of the tumor stroma in resistance to anti-angiogenic therapy.
Several angiogenesis inhibitors are currently used in the clinic for treatment of cancer. While anti-angiogenesis treatment can improve treatment outcome, the overall benefit on patient survival isExpand
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CD44 enhances tumor aggressiveness by promoting tumor cell plasticity
Aggressive tumor cells can obtain the ability to transdifferentiate into cells with endothelial features and thus form vasculogenic networks. This phenomenon, called vasculogenic mimicry (VM), isExpand
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Vaccination against the extra domain‐B of fibronectin as a novel tumor therapy
Monoclonal antibody‐based therapies have made an important contribution to current treatment strategies for cancer and autoimmune disease. However, the cost for these new drugs puts a significantExpand
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Identification of potent biodegradable adjuvants that efficiently break self-tolerance--a key issue in the development of therapeutic vaccines.
Monoclonal antibodies are used successfully in the treatment of many human disorders. However, these antibodies are expensive and have in many countries put a major strain on the health care economy.Expand
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Oncofoetal insulin receptor isoform A marks the tumour endothelium; an underestimated pathway during tumour angiogenesis and angiostatic treatment
BackgroundIn a genomic screen for determinants of the tumour vasculature, we identified insulin receptor (INSR) to mark the tumour endothelium. As a functional role for insulin/INSR in cancer hasExpand
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Therapeutic vaccination against fibronectin ED-A attenuates progression of metastatic breast cancer
Therapeutic vaccination targeting self-molecules is an attractive alternative to monoclonal antibody-based therapies for cancer and various inflammatory diseases. However, development of cancerExpand
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Targeting Serglycin Prevents Metastasis in Murine Mammary Carcinoma
In hematopoietic cells, serglycin proteoglycans mainly contribute to proper storage and secretion of inflammatory mediators via their negatively charged glycosaminoglycans. Serglycin proteoglycansExpand
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An improved conjugate vaccine technology; induction of antibody responses to the tumor vasculature.
The induction of an antibody response against self-antigens requires a conjugate vaccine technology, where the self-antigen is conjugated to a foreign protein sequence, and the co-application of aExpand
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