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Acidic amino acids, such as L-glutamate, are believed to be excitatory neurotransmitters in the mammalian brain1,2 and exert effects on several different receptors named after the selective agonists… (More)
- E. J. Coan, Graham L Collingridge
- Neuroscience Letters
- 1985
The involvement of N-methyl-D-aspartate (NMDA) receptors in synaptic transmission in the Schaffer collateral-commissural pathway of rat hippocampal slices has been examined in the presence and… (More)
- E. J. Coan, Andrew James McGregor Irving, Graham L Collingridge
- Neuroscience Letters
- 1989
In rat hippocampal slices bathed in Mg2(+)-free medium tetanic stimulation generally failed to elicit long-term potentiation (LTP) in the Schaffer collateral-commissural pathway. However, LTP could… (More)
- E. J. Coan, W. Saywood, Graham L Collingridge
- Neuroscience Letters
- 1987
The effect of the anticonvulsant and neuroprotective agent (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5,10-imine maleate (MK-801) has been studied on synaptic events in the CA1 region of… (More)
- Caroline E. Herron, Robin A. J. Lester, E. J. Coan, Graham L Collingridge
- Neuroscience Letters
- 1985
Rat hippocampal CA1 pyramidal neurones were monosynaptically activated via stimulation of the Schaffer collateral-commissural pathway. On changing from a 1 mM Mg2+-containing to a Mg2+-free medium… (More)
- E. J. Coan, Graham L Collingridge
- Neuroscience
- 1987
The involvement of N-methyl-D-aspartate receptors in synaptic transmission from Schaffer collateral-commissural fibres to CA1 neurons has been investigated in rat hippocampal slices. When the… (More)
- Zygmunt Galdzicki, E. J. Coan, Stanley I. Rapoport
- Brain Research
- 1993
Mouse trisomy 16 is an animal model for Down's syndrome (human trisomy 21). The whole-cell patch-clamp technique was used to compare passive and active electrical properties of trisomy 16 and diploid… (More)
- E. J. Coan, Graham L Collingridge
- British journal of pharmacology
- 1987
The effects of representative drugs from three classes of psychotomimetic compounds (arylcyclohexylamines, benzomorphan opioids and dioxolanes) have been examined on synaptic transmission at an… (More)
- Stephen N.G. Davies, Simon Alford, E. J. Coan, Robin A. J. Lester, Graham L Collingridge
- Neuroscience Letters
- 1988
We have examined the voltage dependence of the effects of ketamine on synaptic currents in hippocampal CA1 neurons in vitro under conditions where there is a large N-methyl-D-aspartate (NMDA)… (More)
- Zygmunt Galdzicki, E. J. Coan, Stanley I. Rapoport, James Stoll
- Brain research. Molecular brain research
- 1998
Calcium is an important second messenger that affects metabolic and physiological activities of developing and mature neurons. It has been reported that electrical activity is abnormal in cultured… (More)