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Oxyresveratrol as the potent inhibitor on dopa oxidase activity of mushroom tyrosinase.
  • N. Shin, S. Ryu, +4 authors Y. Kim
  • Chemistry, Medicine
  • Biochemical and biophysical research…
  • 24 February 1998
The results indicate that both the number and positions of hydroxy groups in oxyresveratrol seem to play a critical role in exerting the inhibitory effect on dopa oxidase activity of mushroom tyrosinase. Expand
The bis benzylisoquinoline alkaloids, tetrandine and fangchinoline, enhance the cytotoxicity of multidrug resistance‐related drugs via modulation of P‐glycoprotein
TET and FAN enhanced the cytotoxicity of MDR-related drugs via modulation of P-gp, and could not affect the accumulation and residual rate of rhodamine 123 in SK-OV-3 cells. Expand
Desacetylmatricarin, an anti-allergic component from Taraxacum platycarpum.
The bioassay-guided fractionation of Taraxacum platycarpum (Compositae) extract led to the isolation of a desacetylmatricarin (1) as an active principle responsible for the anti-allergic property. ItExpand
Establishment of doxorubicin-resistant subline derived from HCT15 human colorectal cancer cells
Doxorubicin, one of the clinically most useful anticancer agents, is used alone or in combination with other drugs against a wide variety of tumors, recently. But cancer cells developed resistance toExpand
P-glycoprotein (Pgp) does not affect the cytotoxicity of flavonoids from Sophora flavescens, which also have no effects on Pgp action.
The results suggested that HCT15/CL02 cells had additional mechanisms for drug resistance distinct from Pgp overexpression, and the flavonoids had no effect on the action of Pgp, as well as at nontoxic concentrations. Expand
Reversal of multidrug resistance by novel verapamil analogs in cancer cells
KR-30032 and KR-30035 are active modulators of MDR with potentially minimal cardiovascular toxicity and the cytotoxicity and the accumulation rate of rhodamine are suggested. Expand
Effects of flavonoids on the growth and cell cycle of cancer cells.
It is deemed that the flavonoids tested had diverse cytotoxic mechanisms, and exerted their cell growth inhibitory or killing activity by distinctive ways in different cells. Expand
Anti-allergic actions of the leaves ofCastanea crenata and isolation of an active component responsible for the inhibition of mast cell degranulation
The activity-guided fractionation of the extract led to the isolation of quercetin as an active principle responsible for the inhibition of degranulation as well as the determination of inhibitory effect upon the release of β-hexosaminidase. Expand
Cytotoxicity of trichothecenes to human solid tumor cellsin vitro
The trichothecenes are sesquiterpenoid mycotoxins characterized by the 12,13-epoxytrichothec-9-ene ring system. We have tested cytotoxicity of several naturally-occurring or synthesizedExpand
Novel multidrug-resistance modulators, KR-30026 and KR-30031, in cancer cells.
KR-30026 and KR-30031 are active modulators of MDR with potentially minimal cardiovascular toxicity and verapamil is suggested to be an effective alternative for MDR overcome. Expand