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The Bromodomain Protein Brd4 Insulates Chromatin from DNA Damage Signaling
TLDR
It is discovered that an isoform of Brd4, a bromodomain and extra-terminal (BET) family member, functions as an endogenous inhibitor of DNA damage response signalling by recruiting the condensin II chromatin remodelling complex to acetylated histones through bromidomain interactions. Expand
ESTIMATION AND MANIPULATION OF GLUTATHIONE LEVELS IN PREPUBERAL MOUSE OVARIES AND OVA: RELEVANCE TO SPERM NUCLEUS TRANSFORMATION IN THE FERTILIZED EGG
TLDR
Hormone-induced superovulation was achieved in BSO-treated prepuberal C57B1/6 X SJL mice whose ovaries contained less than 10% of control levels of GSH, and abnormal one-cell embryos resulted in which the maternally derived pronucleus coexisted with an unchanged sperm nucleus, thus confirming that adequate levels ofGSH are necessary for initiating transformation of the fertilizing sperm nucleus. Expand
Endometrin for luteal phase support in a randomized, controlled, open-label, prospective in-vitro fertilization trial using a combination of Menopur and Bravelle for controlled ovarian
TLDR
Pregnancy rates and live birth rates for Endometrin (twice daily and three times daily) were high and similar to those for P(4) gel and the adverse event profiles were similar across groups. Expand
Chromatin decondensation and DNA synthesis in human sperm activated in vitro by using Xenopus laevis egg extracts.
TLDR
Data suggest that phosphoproteins are involved in one or more of the activation events and that a serine protease(s) is involved in the synthesis of DNA. Expand
Relationships between insulin-like growth hormone factor-I and estradiol in reproductive aging.
TLDR
Rising E2 may be a subtle harbinger of the perimenopause and IGF-I and its binding proteins did not decrease with cycle stage or with aging during the reproductive years, perhaps because of increased estradiol stimulation of the somatotrophic axis. Expand
Protein synthetic requirements for the outgrowth of trophoblast cells from mouse blastocysts.
TLDR
Observations are consistent with the view that protein(s) essential for trophoblast outgrowth are synthesized many hours prior to the actual event. Expand
Matched-samples comparison of intramuscular versus vaginal progesterone for luteal phase support after in vitro fertilization and embryo transfer.
TLDR
There are no significant differences in treatment outcomes between vaginal and IM progesterone supplementation, yielding similar clinical pregnancy, miscarriage, and live birth rates. Expand
Single and multidose pharmacokinetic study of a vaginal micronized progesterone insert (Endometrin) compared with vaginal gel in healthy reproductive-aged female subjects.
TLDR
Endometrin vaginal inserts reached higher Cmax, produced greater systemic exposure (area under the curve 0-24), achieved steady state more rapidly, and cleared more rapidly after termination of therapy than the comparator. Expand
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