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Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma.
Phaeochromocytomas (PHEO) and paragangliomas are rare catecholamine-producing tumours. Although 10-30% of these tumours metastasise, histopathological criteria to discriminate malignant from benignExpand
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Pioglitazone improves insulin secretory capacity and prevents the loss of beta-cell mass in obese diabetic db/db mice: Possible protection of beta cells from oxidative stress.
In order to assess the beneficial effect of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist pioglitazone on reduction of mass and alteration of function of pancreatic betaExpand
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Localization of cellubrevin-related peptide, endobrevin, in the early endosome in pancreatic beta cells and its physiological function in exo-endocytosis of secretory granules.
Cellubrevins are integral membrane proteins expressed in a wide variety of tissues and usually localized in recycling vesicles. Here, we investigated the cellular localization of aExpand
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Increased bone resorption may play a crucial role in the occurrence of osteopenia in patients with type 2 diabetes: Possible involvement of accelerated polyol pathway in its pathogenesis.
In order to investigate the underlying mechanism of alterations in bone mineral metabolism in patients with type 2 diabetes, we determined circulating levels of bone functional markers along withExpand
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Increases in plasma ACTH and cortisol after hypertonic saline infusion in patients with central diabetes insipidus.
To clarify the mechanism for the potentiation of CRH-induced ACTH response by the infusion of hypertonic saline, we investigated changes in plasma ACTH concentration after infusion of 5% hypertonicExpand
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Acute inhibition of proinsulin biosynthesis at the translational level by palmitic acid.
The effects of fatty acids on pancreatic beta cell are still controversial. Here, in order to determine whether free fatty acids acutely affect beta cell functions, we studied the effect of palmiticExpand
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Possible involvement of PI3K-dependent pathways in the increased VEGF120 release from osteoblastic cells preloaded with palmitate in vitro.
It have been reported that abnormal bone metabolism often occurs in patients with type 2 diabetes, but the underlying mechanisms remain to be elucidated. In recent years dyslipidemia (hyperlipidemia)Expand
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A large amount of C-Heavy oil spilled accidentally from a Russian oil tanker "Nakhodka" on 2 January 1997 in the sea of Japan and polluted over the coast of Hokuriku district of Japan. The presentExpand
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Biochi ~ ic ~ a et Biophysica A ~ ta Bacterial steroid monooxygenase catalyzing the Baeyer-Villiger oxidation of C 21-ketosteroids from Rhodococcus rhodochrous : the isolation and characterization
Steroid monooxygenase from Rhodococcus rhodochrous, isolated in homogeneity with a high yield, catalyzes Baeyer-Villiger oxidation of progesterone to produce testosterone acetate with theExpand
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