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Cloning and Expression Analysis of a New Member of the Cytochrome P450, CYP2A15 from the Chinese Hamster, Encoding Testosterone 7α-Hydroxylase
A new cytochrome P450 cDNA encoding testosterone 7α-hydroxylase in the Chinese hamster is cloned which shares significant amino acid sequence homology with members of the CYP2A subfamily and was found to hydroxylate testosterone at position 7α in a reconstituted system.
Molecular cloning, heterologous expression, and characterization of a novel member of CYP2A in the Syrian hamster.
- M. Tohkin, K. Kurose, E. Isozaki, M. Fukuhara
- Biology, MedicineBiochimica et biophysica acta
- 3 September 1999
Northern blot analysis showed that CYP2A16 was expressed in kidney and lung while most of the other CYP 2A subfamily members have been reported to be expressed in liver and olfactory, indicating that the Syrian hamster CYP1A16 had unique properties compared with those of other CYp2A sub family members.
Cloning and expression analysis of a new member of the cytochrome P450, CYP2A15 from the Chinese hamster, encoding testosterone 7alpha-hydroxylase.
A new cytochrome P450 cDNA encoding testosterone 7alpha-hydroxylase in the Chinese hamster is cloned which shares significant amino acid sequence homology with members of the CYP2A subfamily and was found to hydroxylate testosterone at position 7alpha in a reconstituted system.