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Effects on mice of numbers of animals per cage: an 18-month study (preliminary results).
Mice were housed 1, 2, 4, or 8 per cage for 18 months. The more densely housed groups showed markedly reduced food consumption, slightly decreased mean body weights, and a smaller variance of bodyExpand
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Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility.
The histologic appearance and cytochemical characteristics of foci of hepatic cellular alteration, hepatic nodules, and hepatocellular carcinomas occurring in male Sprague-Dawley rats treated withExpand
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Effects of housing conditions on food intake, body weight and spontaneous lesions in mice. A review of the literature and results of an 18-month study.
Abstract Mice were housed in groups of one, two, four or eight/cage for 18 months. The more densely housed groups showed markedly reduced food consumption, slightly decreased mean body weights, and aExpand
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A carcinogenicity study in mice of a beta-adrenergic antagonist, primidolol; increased total tumour incidence without tissue specificity.
The beta-adrenergic blocking agent, primidolol hydrochloride, was administered, mixed in the diet, to mice (CD-1, Charles River, France) for 18 months. Experimental groups comprised untreatedExpand
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The relationship of cytochemical changes to the development of chemically induced hepatocellular carcinoma
The morphological and cytochemical changes occurring in liver of male Sprague-Dawley rats receiving clofibrate, diethylnitrosamine (DENA) followed by phenobarbital (PB) and PB alone were studiedExpand
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A cytochemical study of the livers of rats treated with diethylnitrosamine/phenobarbital, with benzidine/phenobarbital, with phenobarbital, or with clofibrate.
Male Sprague-Dawley rats were treated with clofibrate (CLOF) in the diet for 2 years or with 4 i.p. injections of either diethylnitrosamine (DEN) or benzidine (BZ) followed by phenobarbital (PB) inExpand
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Rat Urinary Bladder Hyperplasia Induced by Oral Administration of Carbonic Anhydrase Inhibitors
The carbonic anhydrase inhibitors, acetazolamide and MK-0927, were given by oral route to male Sprague-Dawley rats at 200 mg/kg/day and 25 mg/kg/day, respectively, for up to 4 weeks. SequentialExpand
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Dazoxiben, a Prototype Inhibitor of Thromboxane Synthesis, has Little Toxicity in Laboratory Animals
1 Dazoxiben, an orally active specific inhibitor of thromboxane synthetase, was administered by mouth daily to dogs and rats for 6 months. 2 Dogs showed no evidence of toxicity up to 300 mg day-1Expand
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The Preclinical Toxicity of Dazoxiben: A Specific Inhibitor of Thromboxane A2 Synthetase
The recent discovery of highly selective inhibitors of thromboxane synthetase has opened exciting new therapeutic possibilities in cardiovascular disease, ranging from peripheral vascular disorders,Expand
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