E. Irisarri

Publications10
h-index6
Citations167
Highly Influential Citations1
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Effects on mice of numbers of animals per cage: an 18-month study (preliminary results).
Mice were housed 1, 2, 4, or 8 per cage for 18 months. The more densely housed groups showed markedly reduced food consumption, slightly decreased mean body weights, and a smaller variance of body… Expand
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Hepatic foci of cellular and enzymatic alteration and nodules in rats treated with clofibrate or diethylnitrosamine followed by phenobarbital: their rate of onset and their reversibility.
The histologic appearance and cytochemical characteristics of foci of hepatic cellular alteration, hepatic nodules, and hepatocellular carcinomas occurring in male Sprague-Dawley rats treated with… Expand
  • 49
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Effects of housing conditions on food intake, body weight and spontaneous lesions in mice. A review of the literature and results of an 18-month study.
Abstract Mice were housed in groups of one, two, four or eight/cage for 18 months. The more densely housed groups showed markedly reduced food consumption, slightly decreased mean body weights, and a… Expand
  • 48
A carcinogenicity study in mice of a beta-adrenergic antagonist, primidolol; increased total tumour incidence without tissue specificity.
The beta-adrenergic blocking agent, primidolol hydrochloride, was administered, mixed in the diet, to mice (CD-1, Charles River, France) for 18 months. Experimental groups comprised untreated… Expand
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The relationship of cytochemical changes to the development of chemically induced hepatocellular carcinoma
The morphological and cytochemical changes occurring in liver of male Sprague-Dawley rats receiving clofibrate, diethylnitrosamine (DENA) followed by phenobarbital (PB) and PB alone were studied… Expand
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[Post-natal parasitic infection of piglets in contact with infected mothers. a study of 20 sows and 164 piglets, 42 of which were killed at weaning (author's transl)].
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A cytochemical study of the livers of rats treated with diethylnitrosamine/phenobarbital, with benzidine/phenobarbital, with phenobarbital, or with clofibrate.
Male Sprague-Dawley rats were treated with clofibrate (CLOF) in the diet for 2 years or with 4 i.p. injections of either diethylnitrosamine (DEN) or benzidine (BZ) followed by phenobarbital (PB) in… Expand
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Rat Urinary Bladder Hyperplasia Induced by Oral Administration of Carbonic Anhydrase Inhibitors
The carbonic anhydrase inhibitors, acetazolamide and MK-0927, were given by oral route to male Sprague-Dawley rats at 200 mg/kg/day and 25 mg/kg/day, respectively, for up to 4 weeks. Sequential… Expand
  • 15
Dazoxiben, a Prototype Inhibitor of Thromboxane Synthesis, has Little Toxicity in Laboratory Animals
1 Dazoxiben, an orally active specific inhibitor of thromboxane synthetase, was administered by mouth daily to dogs and rats for 6 months. 2 Dogs showed no evidence of toxicity up to 300 mg day-1… Expand
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The Preclinical Toxicity of Dazoxiben: A Specific Inhibitor of Thromboxane A2 Synthetase
The recent discovery of highly selective inhibitors of thromboxane synthetase has opened exciting new therapeutic possibilities in cardiovascular disease, ranging from peripheral vascular disorders,… Expand
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