• Publications
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Development and characterization of acellular allogeneic arterial matrices.
Surgeons have used cryopreserved vascular allografts successfully for many years to treat arterial occlusive disease and to repair arterial aneurysms. Vascular allografts demonstrate high patencyExpand
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Development and characterization of acellular porcine pulmonary valve scaffolds for tissue engineering.
Currently available replacement heart valves all have limitations. This study aimed to produce and characterize an acellular, biocompatible porcine pulmonary root conduit for reconstruction of theExpand
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2009 Knee Society Presidential Guest Lecture: Polyethylene Wear in Total Knees
Knee arthroplasties in young and active patients place a substantial increase in the lifetime tribological demand and potential for wear-induced osteolysis. Polyethylene materials have advanced inExpand
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Development and characterisation of a low-concentration sodium dodecyl sulphate decellularised porcine dermis
The aim of this study was to adapt a proprietary decellularisation process for human dermis for use with porcine skin. Porcine skin was subject to: sodium chloride (1 M) to detach the epidermis,Expand
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Alternative Bearing Couples in Total Hip Replacements: Solutions for Young Patients
There is now considerable clinical concern about the effect of polyethylene wear debris induced osteolysis in long term failure of hip replacements. This paper compares the wear of stabilised andExpand
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Decellularised intervertebral discs: A potential replacement for degenerate human discs.
Intervertebral disc (IVD) degeneration is a major cause of back pain. Current surgical interventions have limitations. An alternative approach is to replace degenerated IVDs with a natural biologicalExpand
Wear of Historical Polyethylenes in Hip Prostheses. Biomechanical Success and a Biological Failure
Polyethylene wear debris induced osteolysis is a major cause of failure in artificial hip joints. Sub micrometre size particles are taken up by macrophages which are stimulated to release osteolyticExpand
Tissue engineering
Healthy tissue can be “grown” to replace malfunctioning tissue in a range of diseases, write Shiba Sinha and colleagues
Biomechanical assessment of the stability of osteochondral grafts implanted in porcine and bovine femoral condyles
Osteochondral grafts are used clinically to repair cartilage and bone defects and to restore the congruent articulating surfaces of the knee joint following cartilage damage or injury. The clinicalExpand
Development of a specimen-specific in vitro pre-clinical simulation model of the human cadaveric knee with appropriate soft tissue constraints
A human cadaveric specimen-specific knee model with appropriate soft tissue constraints was developed to appropriately simulate the biomechanical environment in the human knee, in order toExpand