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Exporting RNA from the nucleus to the cytoplasm
  • A. Köhler, E. Hurt
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 1 October 2007
The transport of RNA molecules from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear poreExpand
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TREX is a conserved complex coupling transcription with messenger RNA export
The essential yeast proteins Yra1 and Sub2 are messenger RNA export factors that have conserved counterparts in metazoans, designated Aly and UAP56, respectively. These factors couple the machineriesExpand
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Nuclear Export of 60S Ribosomal Subunits Depends on Xpo1p and Requires a Nuclear Export Sequence-Containing Factor, Nmd3p, That Associates with the Large Subunit Protein Rpl10p
ABSTRACT Nuclear export of ribosomes requires a subset of nucleoporins and the Ran system, but specific transport factors have not been identified. Using a large subunit reporter (Rpl25p-eGFP), weExpand
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Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores
An essential cellular factor for nuclear mRNA export called Mex67p which has homologous proteins in human and Caenorhabditis elegans was identified through its genetic interaction with nucleoporinExpand
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Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p
The yeast nuclear protein Yra1p is an essential export factor for mRNA. Yra1p interacts directly with the mRNA transport factor Mex67p/Mtr2p, which is associated with the nuclear pore. Here, weExpand
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The Mex67p‐mediated nuclear mRNA export pathway is conserved from yeast to human
Human TAP is an orthologue of the yeast mRNA export factor Mex67p. In mammalian cells, TAP has a preferential intranuclear localization, but can also be detected at the nuclear pores and shuttlesExpand
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Recruitment of the human TREX complex to mRNA during splicing.
In yeast, the TREX complex contains the THO transcription elongation complex, which functions in direct cotranscriptional recruitment of the mRNA export proteins Sub2 and Yra1 to nascent transcripts.Expand
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The path from nucleolar 90S to cytoplasmic 40S pre‐ribosomes
Recent reports have increased our knowledge of the consecutive steps during 60S ribosome biogenesis substantially, but 40S subunit formation is less well understood. Here, we investigate theExpand
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60S pre‐ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm
60S ribosomes undergo initial assembly in the nucleolus before export to the cytoplasm and recent analyses have identified several nucleolar pre‐60S particles. To unravel the steps in the pathway ofExpand
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Pre-ribosomes on the road from the nucleolus to the cytoplasm.
Eukaryotic ribosomes are assembled in the nucleolus before export to the cytoplasm. Ribosome formation is a highly dynamic and coordinated multistep process, which requires synthesis, processing andExpand
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