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Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects.
  • E. Hunziker
  • Medicine
  • Osteoarthritis and cartilage
  • 1 June 2002
OBJECTIVE To review the basic scientific status of repair in articular cartilage tissue and to assess the efficiency of current clinical therapies instigated for the treatment of structural lesionsExpand
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Perlecan Maintains the Integrity of Cartilage and Some Basement Membranes
Perlecan is a heparan sulfate proteoglycan that is expressed in all basement membranes (BMs), in cartilage, and several other mesenchymal tissues during development. Perlecan binds growth factors andExpand
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Stem cell therapy in a caprine model of osteoarthritis.
OBJECTIVE To explore the role that implanted mesenchymal stem cells may play in tissue repair or regeneration of the injured joint, by delivery of an autologous preparation of stem cells to caprineExpand
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Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture.
This study focuses on the effect of static and dynamic mechanical compression on the biosynthetic activity of chondrocytes cultured within agarose gel. Chondrocyte/agarose disks (3 mm diameter) wereExpand
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Histological Assessment of Cartilage Repair: A Report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS)
Physical injury frequently causes tissue damage, including laceration. Repair of the damage usually results in the formation of a scar; complete anatomic healing and true regeneration are rare. Expand
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Optical and mechanical determination of Poisson's ratio of adult bovine humeral articular cartilage.
The equilibrium stiffness of articular cartilage is controlled by flow-independent elastic properties (Young's modulus, ES, and Poisson's ratio, v(s)) of the hydrated tissue matrix. In the currentExpand
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Physiological mechanisms adopted by chondrocytes in regulating longitudinal bone growth in rats.
1. Chondrocyte activities within growth plate cartilage are the principal determinants of longitudinal bone growth, and it was the aim of this investigation to assess how these cell activities areExpand
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Quantitative structural organization of normal adult human articular cartilage.
OBJECTIVE Data pertaining to the quantitative structural features and organization of normal articular cartilage are of great importance in understanding its biomechanical properties and inExpand
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Tenomodulin Is Necessary for Tenocyte Proliferation and Tendon Maturation
ABSTRACT Tenomodulin (Tnmd) is a member of a new family of type II transmembrane glycoproteins. It is predominantly expressed in tendons, ligaments, and eyes, whereas the only other family member,Expand
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The structural architecture of adult mammalian articular cartilage evolves by a synchronized process of tissue resorption and neoformation during postnatal development.
OBJECTIVE During postnatal development, mammalian articular cartilage acts as a surface growth plate for the underlying epiphyseal bone. Concomitantly, it undergoes a fundamental process ofExpand
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