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Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation.
TLDR
Competition with 5g of creatine monohydrate, four or six times a day for 2 or more days resulted in a significant increase in the total creatine content of the quadriceps femoris muscle measured in 17 subjects, and in some the increase was as much as 50%. Expand
Muscle creatine loading in men.
TLDR
A rapid way to "creatine load" human skeletal muscle is to ingest 20 g of creatine for 6 days, which can be maintained by ingestion of 2 g/day thereafter, and the ingestion of 3 g creatine/day is in the long term likely to be as effective at raising tissue levels as this higher dose. Expand
Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of values.
TLDR
Variation in muscle content of ATP, ATP + ADP + AMP, phosphorylcreatine (PC), creatine (Cr), PC + Cr, and glycogen, between legs, between sites on the same muscle, or as a result of error introduced during analysis, was small compared with the between-individuals variance. Expand
Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis.
TLDR
The data suggest that a dietary-induced increase in muscle total Cr concentration can increase PCr resynthesis during the 2nd min of recovery from intense contraction. Expand
Diet, muscle glycogen and physical performance.
TLDR
It has been shown that the glycogen content and, consequently, the long-term work capacity can be appreciably varied by instituting different diets after glycogen depletion. Expand
Creatine ingestion favorably affects performance and muscle metabolism during maximal exercise in humans.
TLDR
The results suggest that improvements in performance were mediated via improved ATP resynthesis as a consequence of increased PCr availability in type II fibers. Expand
Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man.
TLDR
Investigation of the influence of oral creatine supplementation on skeletal muscle isokinetic torque and the accumulation of plasma ammonia and blood lactate during five bouts of maximal exercise found muscle peak torque production was greater and plasma ammonia accumulation was lower during and after exercise after creatine ingestion. Expand
Creatine supplementation and dynamic high‐intensity intermittent exercise
TLDR
The mechanism responsible for the improved performance with creatine supplementation are postulated to be both a higher initial creatine phosphate content availability and an increased rate of creatine phosphate resynthesis during recovery periods, and the lower blood lactate and hypoxanthine accumulation can be explained by these mechanisms. Expand
The time course of phosphorylcreatine resynthesis during recovery of the quadriceps muscle in man
TLDR
Occlusion of the circulation to the quadriceps completely abolished the resynthesis of PC and Restoration of resynthesis occurred only after release of occlusion. Expand
A study of the glycogen metabolism during exercise in man.
TLDR
The glycogen content of the quadriceps femoris muscle was determined in needle biopsy specimens taken from normal subjects in connexion with muscular work and the carbohydrate metabolism of the liver was studied before and during periods of exercise. Expand
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