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Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus).
- C. Sigurdson, E. Williams, M. Miller, T. Spraker, K. O'Rourke, E. Hoover
- BiologyThe Journal of general virology
- 1 October 1999
It is indicated that CWD PrPres can be detected in lymphoid tissues draining the alimentary tract within a few weeks after oral exposure to infectious prions and may reflect the initial pathway of CWD infection in deer.
Transmission of Prions from Mule Deer and Elk with Chronic Wasting Disease to Transgenic Mice Expressing Cervid PrP
These mice provide a new and reliable tool for detecting CWD prions and Transmission studies indicated that the same prion strain caused CWD in the analyzed mule deer and elk.
Infectious Prions in the Saliva and Blood of Deer with Chronic Wasting Disease
A critical concern in the transmission of prion diseases, including chronic wasting disease (CWD) of cervids, is the potential presence of prions in body fluids. To address this issue directly, we…
Genetic diversity of feline immunodeficiency virus: dual infection, recombination, and distinct evolutionary rates among envelope sequence clades
Analysis of all available FIV env sequences revealed the existence of recombinant viruses generated from subtype A/B, B/D, and A/C envelope gene sequences, consistent with the hypothesis that Fiv-B is an older virus group and is possibly more host adapted than FIV-A.
Identification of three feline immunodeficiency virus (FIV) env gene subtypes and comparison of the FIV and human immunodeficiency virus type 1 evolutionary patterns
- D. Sodora, E. G. Shpaer, B. Kitchell, S. Dow, E. Hoover, J. Mullins
- BiologyJournal of virology
- 1 April 1994
Patterns of FIV genetic diversity are determined by focusing on a 684-nucleotide region encompassing variable regions V3, V4, and V5 of the FIV env gene in order to establish parallels and distinctions between FIV and HIV type 1 (HIV-1).
Feline immunodeficiency virus: a neurotropic lentivirus.
FIV is a neurotropic lentivirus and that FIV infection of feline CNS may serve as a useful model for study of human immune deficiency virus infection of the human CNS.
Feline leukemia virus infection and diseases.
FeLV infection serves as a natural model of the multifaceted pathogenesis of retroviruses and as a paradigm for immunoprophylaxis against an immunosuppressive leukemogenic retrovirus.
Strong sequence conservation among horizontally transmissible, minimally pathogenic feline leukemia viruses
The deduced extracellular glycoproteins of F6A, F3A, and the Glasgow-1 subgroup A isolate of FeLV are 98% homologous, despite having been isolated from naturally infected cats 6 to 13 years apart and from widely different geographic locations.
Detection of CWD Prions in Urine and Saliva of Deer by Transgenic Mouse Bioassay
The presence of infectious prions in the urine and saliva of deer with chronic wasting disease is reported and the detection of infectiousPrion protein in body fluids in other prion infections is portended.
Longitudinal assessment of feline immunodeficiency virus kinetics in plasma by use of a quantitative competitive reverse transcriptase PCR
FIV kinetics are similar to those of HIV-1 during the acute and secondary phase of infection and that the plasma FIV load correlates with the disease stage, according to a quantitative competitive reverse transcriptase PCR method.