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Pharmacology of rioprostil, a new gastric cytoprotective/antisecretory agent.
The animal pharmacology of this compound suggests that it should be useful in the treatment or prophylaxis of peptic ulcer disease and gastric lesions associated with noxious irritants such as ethanol and nonsteroidal antiinflammatory drugs. Expand
Indirect involvement of delta opioid receptors in cholecystokinin octapeptide-induced analgesia in mice.
  • E. Hong, A. Takemori
  • Medicine
  • The Journal of pharmacology and experimental…
  • 1 November 1989
Clinical studies showed that CCK-8-induced analgesia was significantly antagonized by the delta receptor antagonist, ICI154,129 but not by beta-funaltrexamine, a highly selective mu receptor antagonist or nor-binaltorphimine, ahighly selective kappa receptor antagonist. Expand
Evaluation of the teratological potential of the new antihypertensive 5-methoxytryptamine, beta-methylcarboxylate hydrochloride (indorenate) in mice.
There were no differences between control and indorenate-treated groups in the number of implantations, live fetuses or anomalies, however, an embryotoxic effect was observed at 40 and 80 mg/kg, shown by increased resorptions and lower weight of pups at the higher dose. Expand
Biological disposition of 2-(4-phenyl-1-piperazinylmethyl)cyclohexanone-1-C-14 (C-14-MA1050).
The reduced (cyclohexanol) derivative of MA1050 and a metabolite presumed to be its O -glucuronide are found in urine, along with an additional unidentified metabolite. Expand
[Evaluation of the toxicity of indorenate on reproduction].
It was concluded that the parameters of fetal development were not affected by doses of up to 20 mg/kg, which represents approximately 1200 times the proposed dose for hypertensive patients. Expand
General Pharmacology of ADP
Results indicate that ADP does not induce any adverse effects in experimental animals and in in vitro experiments, ADP at the concentration of 150 mg/L did not show direct effect and inhibitory or augmentative action on histamine- or acetylcholine-induced contractions in the isolated ileum of guinea-pig. Expand
On the adrenergic neuron blocking activity of 1-methyl-3-keto-4-phenylquinuclidinium bromide (MA540) during acute and chronic administration.
  • E. Hong
  • Chemistry, Medicine
  • Arzneimittel-Forschung
  • 1976
The results of this study indicate that MA540 may be a useful antihypertensive agent, possessing some advantages over guanethidine, and indicates that adrenergic neuron blocking activity in unanesthetized cats may be inhibited by this derivative. Expand