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- Publications
- Influence
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
- R. Lu, Xiang Zhao, +32 authors W. Tan
- Medicine
- The Lancet
- 30 January 2020
Summary
Background
In late December, 2019, patients presenting with viral pneumonia due to an unidentified microbial agent were… Expand
A new coronavirus associated with human respiratory disease in China
Emerging infectious diseases, such as severe acute respiratory syndrome (SARS) and Zika virus disease, present a major threat to public health 1 – 3 . Despite intense research efforts, how, when and… Expand
A Metagenomic Survey of Microbes in Honey Bee Colony Collapse Disorder
- D. Cox-Foster, S. Conlan, +19 authors W. I. Lipkin
- Biology, Medicine
- Science
- 12 October 2007
In colony collapse disorder (CCD), honey bee colonies inexplicably lose their workers. CCD has resulted in a loss of 50 to 90% of colonies in beekeeping operations across the United States. The… Expand
The proximal origin of SARS-CoV-2
- K. Andersen, Andrew Rambaut, W. I. Lipkin, E. Holmes, R. Garry
- Medicine
- Nature Medicine
- 17 March 2020
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we… Expand
Redefining the invertebrate RNA virosphere
Current knowledge of RNA virus biodiversity is both biased and fragmentary, reflecting a focus on culturable or disease-causing agents. Here we profile the transcriptomes of over 220 invertebrate… Expand
Rates of evolutionary change in viruses: patterns and determinants
- S. Duffy, L. Shackelton, E. Holmes
- Biology, Medicine
- Nature Reviews Genetics
- 1 April 2008
Understanding the factors that determine the rate at which genomes generate and fix mutations provides important insights into key evolutionary mechanisms. We review our current knowledge of the… Expand
New World Bats Harbor Diverse Influenza A Viruses
Aquatic birds harbor diverse influenza A viruses and are a major viral reservoir in nature. The recent discovery of influenza viruses of a new H17N10 subtype in Central American fruit bats suggests… Expand
Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region.
- P. Simmonds, E. Holmes, +7 authors M. Urdea
- Biology, Medicine
- The Journal of general virology
- 1 November 1993
Hepatitis C virus (HCV) showed substantial nucleotide sequence diversity distributed throughout the viral genome, with many variants showing only 68 to 79% overall sequence similarity to one another.… Expand
The genomic and epidemiological dynamics of human influenza A virus
- A. Rambaut, O. Pybus, M. Nelson, C. Viboud, J. Taubenberger, E. Holmes
- Medicine, Biology
- Nature
- 29 May 2008
The evolutionary interaction between influenza A virus and the human immune system, manifest as ‘antigenic drift’ of the viral haemagglutinin, is one of the best described patterns in molecular… Expand
Rates of Molecular Evolution in RNA Viruses: A Quantitative Phylogenetic Analysis
- G. M. Jenkins, A. Rambaut, O. Pybus, E. Holmes
- Medicine, Biology
- Journal of Molecular Evolution
- 1 February 2002
The study of rates of nucleotide substitution in RNA viruses is central to our understanding of their evolution. Herein we report a comprehensive analysis of substitution rates in 50 RNA viruses… Expand