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Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding
Summary Background In late December, 2019, patients presenting with viral pneumonia due to an unidentified microbial agent wereExpand
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A new coronavirus associated with human respiratory disease in China
Emerging infectious diseases, such as severe acute respiratory syndrome (SARS) and Zika virus disease, present a major threat to public health 1 – 3 . Despite intense research efforts, how, when andExpand
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A Metagenomic Survey of Microbes in Honey Bee Colony Collapse Disorder
In colony collapse disorder (CCD), honey bee colonies inexplicably lose their workers. CCD has resulted in a loss of 50 to 90% of colonies in beekeeping operations across the United States. TheExpand
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The proximal origin of SARS-CoV-2
SARS-CoV-2 is the seventh coronavirus known to infect humans; SARSCoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here weExpand
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Redefining the invertebrate RNA virosphere
Current knowledge of RNA virus biodiversity is both biased and fragmentary, reflecting a focus on culturable or disease-causing agents. Here we profile the transcriptomes of over 220 invertebrateExpand
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Rates of evolutionary change in viruses: patterns and determinants
Understanding the factors that determine the rate at which genomes generate and fix mutations provides important insights into key evolutionary mechanisms. We review our current knowledge of theExpand
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New World Bats Harbor Diverse Influenza A Viruses
Aquatic birds harbor diverse influenza A viruses and are a major viral reservoir in nature. The recent discovery of influenza viruses of a new H17N10 subtype in Central American fruit bats suggestsExpand
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Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region.
Hepatitis C virus (HCV) showed substantial nucleotide sequence diversity distributed throughout the viral genome, with many variants showing only 68 to 79% overall sequence similarity to one another.Expand
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The genomic and epidemiological dynamics of human influenza A virus
The evolutionary interaction between influenza A virus and the human immune system, manifest as ‘antigenic drift’ of the viral haemagglutinin, is one of the best described patterns in molecularExpand
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Rates of Molecular Evolution in RNA Viruses: A Quantitative Phylogenetic Analysis
The study of rates of nucleotide substitution in RNA viruses is central to our understanding of their evolution. Herein we report a comprehensive analysis of substitution rates in 50 RNA virusesExpand
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