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Levodopa-induced dyskinesias. Comparison in Parkinsonism-dementia and amyotrophic lateral sclerosis.
TLDR
It is suggested that lesions of the type which produce Parkinson disease increase the susceptibility to levodopa-induced dyskinesias, but that apparently denervation supersensitivity alone does not account for this phenomenon.
Inosiplex and amyotrophic lateral sclerosis. Therapeutic trial in patients on Guam.
TLDR
Most patients, whether given placebo or drug, experienced subjective improvement, and some gained weight during the early phase of the study, but approximately 25% of the patients did not progress clinically during the two years of observation.
Predicting the duration of Guam amyotrophic lateral sclerosis
TLDR
It is found that an early age at onset and male sex were associated with longer survival in amyotrophic lateral sclerosis, and the detailed analysis of degree of involvement of four major neurologic components showed no meaningful pattern of association with duration of illness that could be useful in predicting the course.
Variations in muscle status with age and systemic diseases
TLDR
It is concluded that neoplasms and renal failure may interfere with normal vital processes in the spinal motor neurone and the muscle fiber so as to result in changes akin to those seen in the senium.
Parkinsonism‐dementia of Guam
TLDR
In patients with parkinsonism-dementia of Guam, combined therapy with levodopa and L-alpha-methyldopahydrazine has a considerable advantage over treatment withlevodopa alone and appeared to allow easier control of hypotension and induced dyskinetic and athetoid movements.
Equine analgesia — moving beyond NSAIDS
TLDR
This article will discuss some of the analgesic drugs used less frequently in equids, and strategies that may be of benefit when managing pain in this species.
A Comparison of Slow Trasicor (Oxprenolol 160 mg) and Trasidrex (Oxprenolol 160 mg and Cyclopenthiazide 0.25 mg) in the Treatment of Hypertension in General Practice
TLDR
A crossover study was carried out in general practice to compare Slow Trasicor and Trasidrex in the treatment of newly diagnosed hypertensive patients, with no obvious differences in the incidence of side-effects between the two treatments.