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Differentiation of Mycobacterium tuberculosis complex by PCR amplification of genomic regions of difference.
TLDR
A two-step, multiplex polymerase chain reaction (PCR) method based on genomic regions of difference allowed for rapid differentiation of members of the Mycobacterium tuberculosis complex, making it suitable for routine laboratories and surveillance purposes. Expand
Genome-wide analysis of the structure of the South African Coloured Population in the Western Cape
TLDR
Analysis by means of both the admixture and linkage models in STRUCTURE revealed that the major ancestral components of this population are predominantly Khoesan, Bantu-speaking Africans, European and a smaller Asian contribution, depending on the model used, which is consistent with historical data. Expand
Promoter Variation in the DC-SIGN–Encoding Gene CD209 Is Associated with Tuberculosis
TLDR
The observations suggest that the two −871G and −336A variants confer protection against tuberculosis, and the geographic distribution of these two alleles suggest that they may have increased in frequency in non-African populations as a result of host genetic adaptation to a longer history of exposure to tuberculosis. Expand
Strong maternal Khoisan contribution to the South African coloured population: a case of gender-biased admixture.
TLDR
The overall picture of gender-biased admixture depicted in this study indicates that the modern South African Coloured population results mainly from the early encounter of European and African males with autochthonous Khoisan females of the Cape of Good Hope around 350 years ago. Expand
An Unexpectedly Complex Architecture for Skin Pigmentation in Africans
TLDR
It is demonstrated that skin pigmentation is highly heritable, but known pigmentation loci explain only a small fraction of the variance, and how the architecture of skin Pigmentation can vary across humans subject to different local evolutionary pressures is shown. Expand
Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis.
TLDR
New approaches have provided early evidence for the importance of gene-gene interactions in regulating resistance to disease, and also the prospect that applying host genetics in the field of vaccinomics could lead to a more targeted approach in designing interventions to aid the human immune system in combating mycobacteria. Expand
Investigation of chromosome 17 candidate genes in susceptibility to TB in a South African population.
TLDR
Evidence is presented that haplotypes in the NOS2A promoter influence susceptibility to TB and the importance of NO production in the disease is confirmed. Expand
Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.
TLDR
It is demonstrated that the genetic contribution to TB risk varies between continental populations, and the value of including admixed populations in studies of TB risk and other complex phenotypes is illustrated, and case-only admixture mapping is currently impractical in multi-way admixture populations due to spurious deviations in average local ancestry generated by current local ancestry inference methods. Expand
Association between tuberculosis and a polymorphic NFkappaB binding site in the interferon gamma gene.
TLDR
The transcription factor NFkappaB binds preferentially to the +874T allele, which is over-represented in controls, which suggests that genetically determined variability in interferon gamma and expression might be important for the development of tuberculosis. Expand
Vitamin D receptor gene polymorphisms and sputum conversion time in pulmonary tuberculosis patients.
TLDR
It is concluded that the time taken for an individual to convert to sputum negativity while on antituberculosis therapy can be independently predicted by the VDR genotype. Expand
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