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Zic2 Patterns Binocular Vision by Specifying the Uncrossed Retinal Projection
During CNS development, combinatorial expression of transcription factors controls neuronal subtype identity and subsequent axonal trajectory. Regulatory genes designating the routing of retinalExpand
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Disease states associated with telomerase deficiency appear earlier in mice with short telomeres
Mice deficient for the mouse telomerase RNA (mTR−/−) and lacking telomerase activity can only be bred for approximately six generations due to decreased male and female fertility and to an increasedExpand
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Expression of mouse telomerase catalytic subunit in embryos and adult tissues.
Telomerase is a ribonucleoprotein complex that elongates telomeres, allowing the stable maintenance of chromosomes during multiple cell divisions. Here, we describe the isolation and characterizationExpand
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Zic2-Dependent Axon Midline Avoidance Controls the Formation of Major Ipsilateral Tracts in the CNS
In bilaterally symmetric organisms, interhemispheric communication is essential for sensory processing and motor coordination. The mechanisms that govern axon midline crossing during development haveExpand
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The retinal ganglion cell axon's journey: insights into molecular mechanisms of axon guidance.
The developing visual system has proven to be one of the most informative models for studying axon guidance decisions. The pathway is composed of the axons of a single neuronal cell type, the retinalExpand
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Transcription Factor Foxd1 Is Required for the Specification of the Temporal Retina in Mammals
The organization of the visual system is different in birds and mammals. In both, retinal axons project topographically to the visual targets in the brain; but whereas in birds visual fibers from theExpand
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Telomere shortening in mTR−/− embryos is associated with failure to close the neural tube
Mice genetically deficient for the telomerase RNA (mTR) can be propagated for only a limited number of generations. In particular, mTR−/− mice of a mixed C57BL6/129Sv genetic background are infertileExpand
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Connecting the Retina to the Brain
The visual system is beautifully crafted to transmit information of the external world to visual processing and cognitive centers in the brain. For visual information to be relayed to the brain, aExpand
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Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets
The development of the nervous system is a time‐ordered and multi‐stepped process that requires neural specification, axonal navigation and arbor refinement at the target tissues. Previous studiesExpand
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Massive Telomere Loss Is an Early Event of DNA Damage-induced Apoptosis*
Chromosomal stability and cell viability require a proficient telomeric end-capping function. In particular, telomere dysfunction because of either critical telomere shortening or because of mutationExpand
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