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Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning.
TLDR
Sleep deprivation from 0-5 h after training for this task impaired memory consolidation for contextual fear conditioning whereas sleep deprivation from 5-10H after training had no effect, suggesting that sleep deprivation may act by modifying these molecular mechanisms of memory storage.
Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors
TLDR
The mechanism linking chromatin dynamics to neurobiological phenomena is investigated by applying engineered transcription factors to selectively modify chromatin at a specific mouse gene in vivo and it is found that histone methylation or acetylation at the Fosb locus in nucleus accumbens, a brain reward region, was sufficient to control drug- and stress-evoked transcriptional and behavioral responses.
Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway
TLDR
It is reported that phasic optogenetic activation of this pathway increases BDNF amounts in the nucleus accumbens of socially stressed mice but not of stress-naive mice, unraveling a stress context–detecting function of the brain's mesolimbic circuit.
MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes
TLDR
Small RNA-sequencing in paired samples from MDD patients enrolled in a large, randomized placebo-controlled trial of duloxetine collected before and 8 weeks after treatment revealed differential expression of microRNAs according to treatment response, indicating that these miRNAs are consistent markers of treatment response and regulators of the MAPK/Wnt systems.
Essential Role of SIRT1 Signaling in the Nucleus Accumbens in Cocaine and Morphine Action
TLDR
These studies establish sirtuins as key mediators of the molecular and cellular plasticity induced by drugs of abuse in NAc, and of the associated behavioral adaptations, and point toward novel signaling pathways involved in drug action.
Loss of BDNF Signaling in D1R-Expressing NAc Neurons Enhances Morphine Reward by Reducing GABA Inhibition
TLDR
Evidence is provided for the enhancement of morphine reward through reduction of inhibitory GABAAR responses, an adaptation mediated by morphine-induced reduction of BDNF-TrkB signaling in D1-type MSNs in the NAc.
ACF chromatin remodeling complex mediates stress–induced depressive–like behavior
TLDR
It is established that persistent upregulation of the ACF (ATP-utilizing chromatin assembly and remodeling factor) ATP-dependent chromatin-remodeling complex, occurring in the nucleus accumbens of stress-susceptible mice and depressed humans, is necessary for stress-induced depressive-like behaviors.
SIRT1-FOXO3a Regulate Cocaine Actions in the Nucleus Accumbens
TLDR
It is demonstrated that overexpressing FOXO3a in NAc enhances cocaine place conditioning, and directly establishes a role for FOXO 3a in promoting cocaine-elicited behavioral responses by use of viral-mediated gene transfer.
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