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Production and characterization of a camelid single domain antibody-urease enzyme conjugate for the treatment of cancer.
- B. Tian, W. Wong, E. Hegmann, K. Gaspar, Praveen Kumar, H. Chao
- Biology, ChemistryBioconjugate chemistry
- 14 May 2015
A novel immunoconjugate (L-DOS47) was developed and characterized as a therapeutic agent for tumors expressing CEACAM6 and is being investigated as a potential therapeutic agent in human phase I clinical studies for nonsmall cell lung cancer.
Binary mixtures of bent-core molecules forming distinct types of B4 phase nano- and microfilament morphologies
ABSTRACT The remarkable ability of certain molecules with a bent molecular shape to form hierarchically self-assembled helical building blocks with negative Gaussian or cylindrical curvature…
Molecular Conformation of Bent-Core Molecules Affected by Chiral Side Chains Dictates Polymorphism and Chirality in Organic Nano- and Microfilaments.
This work demonstrates how a priori calculations of the molecular conformation affected by chiral side chains are used to design bent-shaped molecules that self-assemble into chiral nano- and microfilament as well as nanocylinder conglomerates despite the homochiral nature of the molecules.
Biocompatible, biodegradable and porous liquid crystal elastomer scaffolds for spatial cell cultures.
- A. Sharma, A. Neshat, E. Hegmann
- Materials Science, EngineeringMacromolecular bioscience
- 1 February 2015
Preliminary cell studies focused on characterizing the elastomer-based scaffolds' biocompatibility and the successful 3D incorporation as well as growth of cells in 60 to 150-μm thick elastomers.
Liquid Crystal Elastomers—A Path to Biocompatible and Biodegradable 3D-LCE Scaffolds for Tissue Regeneration
3D LCEs are ideal materials for new insights to simulate and study the development of tissues and the complex interplay between cells, as well as the integration of a few technologies for the preparation of more sophisticated LCE-composite scaffolds for more dynamic biomaterials.
Biocompatible 3D Liquid Crystal Elastomer Cell Scaffolds and Foams with Primary and Secondary Porous Architecture.
3D biodegradable and highly regular foamlike cell scaffolds based on biocompatible side-chain liquid crystal elastomers have been prepared. Scaffolds with a primary porosity characterized by…
Liquid Crystal Elastomer Microspheres as Three-Dimensional Cell Scaffolds Supporting the Attachment and Proliferation of Myoblasts.
- T. Bera, E. Freeman, E. Hegmann
- Materials Science, BiologyACS applied materials & interfaces
- 25 June 2015
Confocal microscopy experiments clearly established that LCEs with a globular, porous morphology permit both attachment and proliferation of C2C12 myoblasts, while the nonporous elastomer morphology, prepared in the absence of a microemulsion, does not.
Biphenyl-based liquid crystals for elevated temperature processing with polymers
Due to the limited thermal stability of current commercially available liquid crystals (LCs), the incorporation into polymer composites through standard processing techniques, such as melt…
Liquid crystal elastomer foams with elastic properties specifically engineered as biodegradable brain tissue scaffolds.
This research provides a new platform to analyse LCE scaffold-cell interactions where the presence of liquid crystal moieties promotes cell alignment paving the way for a stimulated brain-like tissue.
Synchrotron Microbeam Diffraction Studies on the Alignment within 3D-Printed Smectic-A Liquid Crystal Elastomer Filaments during Extrusion
3D printing of novel and smart materials has received considerable attention due to its applications within biological and medical fields, mostly as they can be used to print complex architectures…