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Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence
Spatial partitioning of the regulatory landscape of the X-inactivation centre
In addition to uncovering a new principle of cis-regulatory architecture of mammalian chromosomes, this study sets the stage for the full genetic dissection of the mouse X-inactivation centre.
HiC-Pro: an optimized and flexible pipeline for Hi-C data processing
This work applied HiC-Pro to different Hi-C datasets, demonstrating its ability to easily process large data in a reasonable time and its fast implementation of the iterative correction method.
Mouse Polycomb Proteins Bind Differentially to Methylated Histone H3 and RNA and Are Enriched in Facultative Heterochromatin
- E. Bernstein, E. M. Duncan, O. Masui, J. Gil, E. Heard, C. Allis
- Biology, ChemistryMolecular and Cellular Biology
- 1 April 2006
It is proposed that the capacity of this mouse Polycomb homolog to associate with the inactive X chromosome, or any other region of chromatin, depends not only on its chromodomain but also on the combination of histone modifications and RNA molecules present at its target sites.
Epigenetic Dynamics of Imprinted X Inactivation During Early Mouse Development
It is shown that although initially active, the paternal X chromosome undergoes imprinted inactivation from the cleavage stages, well before cellular differentiation, which reveals the remarkable plasticity of the X-inactivation process during preimplantation development and underlines the importance of the ICM in global reprogramming of epigenetic marks in the early embryo.
Systematic Discovery of Xist RNA Binding Proteins
A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced.
It is proposed that Xist RNA has multiple functions: A-repeat-independent creation of a transcriptionally silent nuclear compartment; and A- Repeat-dependent induction of gene repression, which is associated with their translocation into this silent domain.
Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts
Based on gene expression analysis, chimera studies and imprinted X-inactivation, XEN cell lines are representative of extra-embryonic endoderm and provide a new cell culture model of an early mammalian lineage.
Transgenerational Epigenetic Inheritance: Myths and Mechanisms