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Characterization of the human hepatic cytochromes P450 involved in the in vitro oxidation of clozapine.
It was aimed to identify the cytochrome(s) P450 (CYPs) involved in the N-demethylation and N-oxidation of clozapine (CLZ) by various approaches using human liver microsomes or microsomes from humanExpand
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Characterization of rat liver microsomal metabolites of clivorine, an hepatotoxic otonecine-type pyrrolizidine alkaloid.
  • G. Lin, Y. Cui, E. Hawes
  • Biology, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 December 2000
The metabolism of the hepatotoxic otonecine-type pyrrolizidine alkaloid (PA), clivorine, was investigated using rat liver microsomes. The metabolites dehydroretronecine (DHR),Expand
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Stability and enzymatic hydrolysis of quaternary ammonium-linked glucuronide metabolites of drugs with an aliphatic tertiary amine-implications for analysis.
Quaternary ammonium-linked glucuronide (N+-glucuronide) metabolites formed at aliphatic tertiary amine functional groups of xenobiotics have not been previously systematically studied with respect toExpand
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N+-glucuronidation, a common pathway in human metabolism of drugs with a tertiary amine group.
  • E. Hawes
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 September 1998
Glucuronidation of either an aliphatic or aromatic tertiary amine group in a molecule results in a quaternary ammonium-linked glucuronide metabolite (i.e. N+-glucuronide). The development of soundExpand
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Microsomal N-glucuronidation of nicotine and cotinine: human hepatic interindividual, human intertissue, and interspecies hepatic variation.
  • O. Ghosheh, E. Hawes
  • Biology, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 December 2002
Two of the abundant conjugates of human nicotine metabolism result from the N-glucuronidation of S-(-)-nicotine and S-(-)-cotinine, transformations we recently demonstrated in liver microsomes. WeExpand
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N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases.
  • O. Ghosheh, E. Hawes
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 September 2002
Two predominant human glucuronide metabolites of nicotine result from pyridine nitrogen atom conjugation. The present objectives included determination of the kinetics of formation of S(-)-cotinineExpand
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In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine
In vitro studies were conducted to identify the hepatic cytochrome P450 (CYP) enzymes responsible for the oxidative metabolism of loxapine to 8‐hydroxyloxapine, 7‐hydroxyloxapine, N‐desmethylloxapineExpand
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Psychologic distress in women with abnormal findings in mass mammography screening
This study was conducted to explore the psychologic morbidity of women recalled for diagnostic assessment during population‐based mammographic screening.
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N-oxygenation of clozapine by flavin-containing monooxygenase.
The involvement of FMO in the N-oxygenation of CLZ was investigated by use of purified FMOs and human liver microsomes that contained the mean amount of immunoreactive FMO3 relative to other humanExpand
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Logarithmic transformation in bioequivalence: application with two formulations of perphenazine.
The rationale for using the logarithmic transformation on concentration-dependent pharmacokinetic parameters a priori is presented. This rationale is based on theoretical pharmacokinetic andExpand
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