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Molecular signature of hypersaline adaptation: insights from genome and proteome composition of halophilic prokaryotes
BackgroundHalophilic prokaryotes are adapted to thrive in extreme conditions of salinity. Identification and analysis of distinct macromolecular characteristics of halophiles provide insight into theExpand
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The BvgAS virulence control system regulates type III secretion in Bordetella bronchiseptica
The BvgAS signal transduction system in Bordetella spp. mediates a transition between infectious (Bvg+) and non‐infectious (Bvg−) phases by sensing environmental conditions and regulating geneExpand
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Modulation of host immune responses, induction of apoptosis and inhibition of NF‐κB activation by the Bordetella type III secretion system
Bordetella bronchiseptica establishes respiratory tract infections in laboratory animals with high efficiency. Colonization persists for the life of the animal and infection is usually asymptomaticExpand
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Probing the Function of Bordetella bronchiseptica Adenylate Cyclase Toxin by Manipulating Host Immunity
ABSTRACT We have examined the role of adenylate cyclase-hemolysin (CyaA) by constructing an in-frame deletion in the Bordetella bronchiseptica cyaA structural gene and comparing wild-type andcyaAExpand
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Pertussis toxin inhibits neutrophil recruitment to delay antibody-mediated clearance of Bordetella pertussis.
Whooping cough is considered a childhood disease, although there is growing evidence that children are infected by adult carriers. Additionally, increasing numbers of vaccinated adults are beingExpand
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Role of Antibodies in Immunity to Bordetella Infections
ABSTRACT The persistence of Bordetellapertussis and B. parapertussis within vaccinated populations and the reemergence of associated disease highlight the need to better understand protectiveExpand
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Multiple Roles for BordetellaLipopolysaccharide Molecules during Respiratory Tract Infection
ABSTRACT Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica are closely related subspecies that cause respiratory tract infections in humans and other mammals and expressExpand
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Global Population Structure and Evolution of Bordetella pertussis and Their Relationship with Vaccination
ABSTRACT Bordetella pertussis causes pertussis, a respiratory disease that is most severe for infants. Vaccination was introduced in the 1950s, and in recent years, a resurgence of disease wasExpand
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Evolution and emergence of Bordetella in humans.
Two highly infectious bordetellae, Bordetella pertussis and B. parapertussis, have emerged in historical times as co-dominant in human populations. Both of these cause acute disease (whooping cough),Expand
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