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Molecular Pathogenesis of Infections Caused by Legionella pneumophila
TLDR
The factors that contribute to the ability of L. pneumophila to infect and replicate in human cells and amoebae are reviewed with an emphasis on proteins that are secreted by the bacteria into the Legionella vacuole and/or the host cell. Expand
Identification of a Novel Fimbrial Gene Cluster Related to Long Polar Fimbriae in Locus of Enterocyte Effacement-Negative Strains of Enterohemorrhagic Escherichia coli
TLDR
Deletion of the putative major fimbrial subunit gene, lpfA, from EHEC O113:H21 resulted in decreased adherence of this strain to epithelial cells, suggesting that l pfO113 may function as an adhesin in LEE-negative isolates of EH EC. Expand
A type III effector antagonises death receptor signalling during bacterial gut infection
TLDR
The activity of NleB suggests that EPEC and other attaching and effacing pathogens antagonize death-receptor-induced apoptosis of infected cells, thereby blocking a major antimicrobial host response. Expand
The Type III Effectors NleE and NleB from Enteropathogenic E. coli and OspZ from Shigella Block Nuclear Translocation of NF-κB p65
TLDR
Overall the data show that EPEC and Shigella have evolved similar T3SS-dependent means to manipulate host inflammatory pathways by interfering with the activation of selected host transcriptional regulators. Expand
Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements
TLDR
The findings have highlighted the multifunctional nature of the effectors and their ability to participate in redundant, synergistic or antagonistic relationships, acting in a co‐ordinated spatial and temporal manner on different host organelles and cellular pathways during infection. Expand
The Legionella pneumophila F‐box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication
TLDR
The environmental pathogen Legionella pneumophila encodes three proteins containing F‐box domains and additional protein–protein interaction domains, reminiscent of eukaryotic SCF ubiquitin–protein ligases, which are shown to be effectors involved in the accumulation of ubiquitinated proteins associated with the Legionella‐containing vacuole. Expand
Discovery of an archetypal protein transport system in bacterial outer membranes
TLDR
The discovery of a new translocation and assembly module (TAM) that promotes efficient secretion of autotransporters in proteobacteria is discovered and provides a new target for the development of therapies to inhibit colonization by bacterial pathogens. Expand
Contribution of Efa1/LifA to the adherence of enteropathogenic Escherichia coli to epithelial cells.
TLDR
The data suggest that Efa1 has host cell binding activity, at least in tissue culture, and that it is produced during infection, suggesting that EFA1 may play a direct role in the pathogenesis of infections caused by A/E pathogens. Expand
A Screen of Coxiella burnetii Mutants Reveals Important Roles for Dot/Icm Effectors and Host Autophagy in Vacuole Biogenesis
TLDR
A functional Cig2 protein is important for interactions between the CCV and host autophagosomes and this drives a process that enhances the fusogenic properties of this pathogen-occupied organelle. Expand
A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-κB for degradation
TLDR
It is concluded that NleC is a type III effector protease that degrades NF‐κB thereby contributing the arsenal of bacterial effectors that inhibit innate immune activation. Expand
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